Abstract

The study was carried out to evaluate the effects of equine resveratrol supplement (equithrive joint^TM) on inflammatory indices in ageing and lame horses. 16 horses of both sexes aged 18±0.65 years, showing lameness grade 3 were used for the study. The horses weighed 350-450 kg and were randomly assigned to treated and untreated groups comprising 8 horses each. Treated group were administered with resveratrol supplement for 4 weeks while the untreated group were given only Saccharomyces cerevisiae yeast strain used as carrier in the supplement. Blood samples were collected from each animal before supplementation on week 0 and then weekly for four weeks of supplementation. Markers of inflammation consisting of Tumour Necrosis Factor-alpha (TNFα), Erythrocyte Sedimentation Rate (ESR), haematocrit level and serum protein concentration were determined by standard methods. Equithrive joint TM supplementation reduced significantly (p<0.05) the values of TNF-α concentration, ESR and serum protein in the treated horses compare with the controls. The haematocrit level was significantly (p<0.05) higher in treated horses compared with the controls. It was concluded that equithrive joint TM is a potent anti-inflammatory agent capable of reducing inflammatory mediators and thereby enabling horses move with ease particularly during ageing.

Keywords:

Erythrocyte sedimentation rate, horse, inflammation, resveratrol, tumour necrosis factor-alpha,

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