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     International Journal of Animal and Veterinary Advances


Effects of Prolonged Empirical Antibiotic Administration on Post-Surgical Intestinal Bacterial Flora of Local Dogs Undergoing Non-Laparoscopic Gastrectomy

1J.F. Akinrinmade, 1Gladys O. Melekwe and 2Adenike A.O. Ogunshe
1Department of Veterinary Surgery and Reproduction, Faculty of Veterinary Medicine
2Applied Microbiology and Infectious Diseases, Department of Microbiology, Faculty of Science, University of Ibadan, Nigeria
International Journal of Animal and Veterinary Advances  2015  3:40-48
http://dx.doi.org/10.19026/ijava.7.5239  |  © The Author(s) 2015
Received: August 25, 2012  |  Accepted: September 19, 2012  |  Published: July 20, 2015

Abstract

Prolonged post-surgical antibiotic administration may be of less advantage in prevention of post-surgical infections. This study therefore, aimed at investigating the prolonged effect of empiric administration of three most-prescribed antibiotics (amoxicillin, cefotaxime and oxytetracycline) by veterinary practices in Southwest Nigeria on intestinal bacterial population of dogs undergoing partial, non-laparoscopic gastrectomy. Using conventional quantitative and qualitative microbial culture procedures, the total bacterial populations were mostly too numerous to count (TNTC) before gastrectomy but log103-105 cfu/mL after, while control were log 105-107 cfu/mL after gastrectomy. On general-purpose, special, differential and selective culture media, total bacterial counts with increasing post-operative days were- amoxicillin (11 mg/kg) day 4: log 105-10-9/TNTC cfu/mL vs. day 8: log 103-105 cfu/mL; cefotaxime (25 mg/kg) day 4: log 103-108/TNTC/cfu/mL vs. day 8: log 102-105 cfu/mL; oxytetracycline (10 mg/kg) day 4: log 104-109 TNTC cfu/mL vs. day 8: log 102-106 cfu/mL. Total bacterial counts of control animals were- day 4: log 105-108/TNTC cfu/mL vs. day 8: log 105-109. Total qualitative populations of predominant, easily-recoverable aerobic and anaerobic rectal canine bacteria, >Bacillus, Citrobacter aerogenes, Clostridium, E. coli, Klebsiella, Enterobacter, Proteus, Pseudomonas, Salmonella, Shigella, Streptococcus, Staphylococcus and lactobacilli were significantly less after gastrectomy but reductions in post-operative bacterial populations were mostly more pronounced among the anaerobes (lactobacilli and Clostridium perfringens). No post-operative infection was recorded among all the experimental animals, including the control animals. In conclusion, this study confirmed significant reduction effect of prolonged empiric antibiotic administration on rectal (intestinal) bacterial populations of experimental local dogs that had partial, non-laparoscopic gastrectomy.

Keywords:

Canine bacterial populations, colonisation resistance, dogs, post-operative infection, veterinary gastrointestinal surgery, veterinary practices and public health, zoo noses,


References


Competing interests

The authors have no competing interests.

Open Access Policy

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Copyright

The authors have no competing interests.

ISSN (Online):  2041-2908
ISSN (Print):   2041-2894
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