Abstract

Effect of intramuscular administration of Trypanocides on body temperature, body weight and hematological parameters of Wistar rats infected with Trypanosoma brucei brucei was investigated. Twenty-five adult Wistar rats were randomly divided into 5 groups. Group A uninfected untreated, group B were infected with 1×10⁶ of the parasites. Groups C, D and E were administered the same dose as in group B and were treated with 3.5 mg/kg b.w. of Trypadim® (Diminazene di-aceturate); 1 mg/kg b.w. of Trypamidium® (Isometamidium chloride) and 1 mg/kg b.w. of Novidium® (Homidium chloride), respectively. PCV, WBC, Neutrophil were significantly (p<0.05) higher in groups C, D and E compared to group B. However, the same level of significance (p<0.05) was observed for eosinophil but in a decreasing pattern. Body temperature increased consistently in all groups except group A. There was a significant (p<0.05) difference in all treated groups compared to group B on day 7 and 28 post-infection. Body weight decreased significantly (p≤0.01) in group B compared to the initial and final values. Both vitamins in their separate administration demonstrated trypanocidal and anti-pyrexia activities and therefore we recommend further studies of their combined usage in order to evaluate its synergistic effect in combating or ameliorating the problem of drug resistance in trypanosomiasis.

Keywords:

Body temperature, hematological parameters, novidium®, trypadim®, trypamidium®, Trypanosoma brucei brucei (Federe strain), , wistar rats,

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