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2010 (Vol. 2, Issue: 7)
Article Information:

Studies on Antivenom Activity of Ceiba pentandra Leaves’ Aqueous Methanol Extract Against Echis ocellatus’ Snake Venom

S. Sarkiyayi, S. Ibrahim and M.S. Abubakar
Corresponding Author:  sarkiyayi shehu 

Key words:  Antivenom, Ceiba pentandra, Echis ocellatus, phospholipase A2, plant, snake venom,
Vol. 2 , (7): 687-694
Submitted Accepted Published
2010 April, 23 2010 June, 08 2010 October, 25
Abstract:

Aqueous methanol of Ceiba pentandra leaves extract was tested for antivenom activity against Echis ocellatus snake venom. Among parameters investigated include: LD50 of the Echis ocellatus snake venom, phospholipase A2 activity, percentage hemolysis. In vivo analysis of total protein content, white blood cells, pack cell volume and haemoglobin contents were also investigated. The result reveals that Echis ocellatus has an LD50 of 0.280mg/kg ± 0.065. Haemolysis due to venom has drastically reduced by the extract from 66% to 27.4%. suggesting that the extract is effective in reducing haemolysis in mice. The in vivo studies reveals that there were significant (p<0.05) decrease in packed cell volume, total protein and haemoglobin contents for the venom group and there was only slight changes in the venom/extract and control groups suggesting that the extract has some inhibitory effect on the venom activity. The purified phospholipase incubated with the extract demonstrated neutralization effect against the phospholipase A2 activity. The result has shown that Ceiba pentandra leaves extract possess potent snake venom-neutralizing capacity. The plant leaves extract could be use as an antidote for snakebite envenomation.
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  Cite this Reference:
S. Sarkiyayi, S. Ibrahim and M.S. Abubakar, 2010. Studies on Antivenom Activity of Ceiba pentandra Leaves’ Aqueous Methanol Extract Against Echis ocellatus’ Snake Venom.  Research Journal of Applied Sciences, Engineering and Technology, 2(7): 687-694.
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ISSN (Online):  2040-7467
ISSN (Print):   2040-7459
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