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Abstract
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Article Information:
Morphological and Biochemical Effects of Crude Aqueous Extract of Mangifera indica L. (Mango) Stem Bark on the Liver in Wistar Rats
A.M. Izunya, A.O. Nwaopara, A. Aigbiremolen, M.A.C. Odike, G.A. Oaikhena, J.K. Bankole and P.A. Ogarah
Corresponding Author: Al-Hassan M. Izunya
Submitted: 2010 May, 19
Accepted: 2010 June, 01
Published: 2010 August, 01 |
Abstract:
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The objective of this study was to investigate the effects of Mangifera indica L. (mango) stem bark
crude Aqueous Extract (AE) on the morphology and biochemical functions of the liver in wistar rats. Adult
wistar rats used in the study were divided into 2 groups: Group 1 rats were untreated and served as control and
Group 2 experimental rats were orally given 1 mL (100 mg) daily of aqueous extract for a period of 14 days.
The body weight changes and the weight of the liver were measured and the serum aspartate aminotransferase
(AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), Total Bilirubin (TB) and Conjugated
Bilirubin (CB) levels were determined. There was no significant difference (p<0.05) in body weight gain
between the two groups at the end of the experiment. The treated group had a significant decrease in liver
weight (p<0.05) when compared with control. The treated group also had a significant increase in AST when
compared with control. There were no significant increases in ALT, ALP and total bilirubin when compared
with the control. The study suggests derangement of liver function and possible damage to the hepatocytes by
the crude AE at this dose and duration.
Key words: Aqueous extract, liver, Mangifera indica, toxicity, wistar rats, ,
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Abstract
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Cite this Reference:
A.M. Izunya, A.O. Nwaopara, A. Aigbiremolen, M.A.C. Odike, G.A. Oaikhena, J.K. Bankole and P.A. Ogarah, . Morphological and Biochemical Effects of Crude Aqueous Extract of Mangifera indica L. (Mango) Stem Bark on the Liver in Wistar Rats. Research Journal of Applied Sciences, Engineering and Technology, (5): Page No: 460-465.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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