Home           Contact us           FAQs           
 
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
    Abstract
2012 (Vol. 4, Issue: 15)
Article Information:

Efficacy of Di-n-octyl Phthalate Anti Venom Isolated from Ceiba pentandra Leaves Extract in Neutralization of Echis ocellatus Venom

S. Ibrahim, J.A. Nok, M.S. Abubakar and S. Sarkiyayi
Corresponding Author:  S. Ibrahim 

Key words:  Ceiba pentandra, di-n-octyl phthalate, Echis ocellatus, PLA2 activity, , ,
Vol. 4 , (15): 2382-2387
Submitted Accepted Published
January 02, 2012 March 15, 2012 August 01, 2012
Abstract:

The aim of the study is to investigate the efficacy of Di-n-octyl phthalate isolated from Ceiba pentandra leaves extract for its anti Echis ocellatus venom properties. The leaves of Ceiba pentandra was extracted with aqueous methanol, partitioned on column chromatography and subjected to TLC and preparative TLC. The isolate was tested for its anti venom activity and submitted to IR and GCMS for structural elucidation. Our findings revealed that the isolate was biologically active in inhibiting PLA2 activity in a dose dependent manner. The IR analysis showed that the isolate has a carbonyl functional group and aromatic ring and the GCMS analysis revealed that the compound isolated was Di-n-octyl phthalate with molecular weight 391. The inhibitor (Di-n-octyl phthalate) isolated during this research might become a highly effective therapeutic agent for the reducing of snake bite envenomation. The relevance of these findings would be of importance in the area of development of anti snake bite drugs that are going to be effective, cheap, accessible and less allergic plant compound that can be scientifically explored.
Abstract PDF HTML
  Cite this Reference:
S. Ibrahim, J.A. Nok, M.S. Abubakar and S. Sarkiyayi, 2012. Efficacy of Di-n-octyl Phthalate Anti Venom Isolated from Ceiba pentandra Leaves Extract in Neutralization of Echis ocellatus Venom.  Research Journal of Applied Sciences, Engineering and Technology, 4(15): 2382-2387.
    Advertise with us
 
ISSN (Online):  2040-7467
ISSN (Print):   2040-7459
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved