Home           Contact us           FAQs           
 
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
    Abstract
2012 (Vol. 4, Issue: 12)
Article Information:

Hepatoprotective Activity of Aqueous Acetone Extract from Cienfuegosia digitata Cav. (Malvaceae) Against Alcohol Hepatotoxicity in Albinos Wistar Rats

K. Konaté, M. Ouédraogo, M.B. Ouattara, I.C. Dibala, J.F. Mavoungou, A.N. Lepengué, A. Souza, B.M. Batchi and O.G. Nacoulma
Corresponding Author:  Konaté Kiessoun 

Key words:  Cienfuegosia digitata Cav, biochemical parameters, hepatoprotective activity, Albinos Wistar rats, alcohol, Hepatotoxicity,
Vol. 4 , (12): 1637-1641
Submitted Accepted Published
February 04, 2011 March 08, 2011 June 15, 2012
Abstract:

The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract of Cienfuegosia digitata Cav. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally liver disease in albinos Wistar rats. Animals received by gavage 25, 50 and 100 mg/kg body weight of extract daily for a period of 28 days. Control groups received alcohol 35% and water. In vivo administration of 35% ethanol for a period of 28 days in rats showed an activity of liver marker enzymes (AST, ALT, ALP and GGT), triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum compared with rats which received water (control water). However, administration of 35% ethanol along with aqueous acetone extract decreased the activities of liver markers enzyme in serum comparatively to the control water group (p<0.05 or p<0.01). We noticed that extract at a dose of 100 mg/kg body weight was highly effective than 25 and 50 mg/kg body weight compared to the control water group (ALT and ALP; p>0.05 and p<0.05). This study revealed that Cienfuegosia digitata presents a hepatoprotective potential and this plant could be traditionally exploited in the treatment of liver disease particularly hepatitis B in Burkina Faso.
Abstract PDF HTML
  Cite this Reference:
K. Konaté, M. Ouédraogo, M.B. Ouattara, I.C. Dibala, J.F. Mavoungou, A.N. Lepengué, A. Souza, B.M. Batchi and O.G. Nacoulma, 2012. Hepatoprotective Activity of Aqueous Acetone Extract from Cienfuegosia digitata Cav. (Malvaceae) Against Alcohol Hepatotoxicity in Albinos Wistar Rats.  Research Journal of Applied Sciences, Engineering and Technology, 4(12): 1637-1641.
    Advertise with us
 
ISSN (Online):  2040-7467
ISSN (Print):   2040-7459
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved