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     Research Journal of Applied Sciences, Engineering and Technology

    Abstract
2011(Vol.3, Issue:11)
Article Information:

Synthesis, Physico-Chemical and Antimicrobial Properties of Co(II), Ni(II), and Cu(II) Mixed-Ligand Complexes of Dimethylglyoxime

A.A. Osunlaja, N.P. Ndahi, J.A Ameh and A. Adetoro
Corresponding Author:  A.A. Osunlaja 
Submitted: 2011 July, 22
Accepted: 2011 September, 08
Published: 2011 November, 25
Abstract:
The synthesis of non-electrolyte mixed-ligand complexes of the general formula [M(Hdmg)B], where M = Co(II), Ni(II) or Cu(II) Hdmg = dimethylglyoximato monoanion, B = 2- aminophenol(2-aph), diethylamine (dea) or malonic acid (MOH) are described. Metal analysis, melting points, solubility, conductivity, IR and UV/Visible electronic spectra were used in determining their physico-chemical properties. The antimicrobial activities of the complexes were tested against Esherichia coli, Staphylococcus aureus, Aspergillus niger and Aspergillus flavus. The complexes melted/decomposed at 120-306ÂșC and, most of them dissolved only in polar solvents. The colours of the complexes are mostly dark - brown or red. The spectral results suggest the binding of Hdmg, 2-amino phenol or malonic acid through the N atom and O atoms respectively to the metal ion In the electronic spectra of the complexes, the absorption bands observed in the UV/Visible region are presumed to be either due to charge transfer or intra-ligand transitions from the ligands or d-d transitions from the metal ions. The complexes showed marked antimicrobial activity against the tested microbes at 10 mg/mL. The possible use of the complexes as chemotherapeutic agents is hereby suggested.

Key words:  Antimicrobial activity, dimethylglyoxime, infrared spectroscopy, mixed - ligand, UV/Visible spectroscopy, ,
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Cite this Reference:
A.A. Osunlaja, N.P. Ndahi, J.A Ameh and A. Adetoro, . Synthesis, Physico-Chemical and Antimicrobial Properties of Co(II), Ni(II), and Cu(II) Mixed-Ligand Complexes of Dimethylglyoxime. Research Journal of Applied Sciences, Engineering and Technology, (11): 1233-1238.
ISSN (Online):  2040-7467
ISSN (Print):   2040-7459
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