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    Abstract
2009 (Vol. 1, Issue: 1)
Article Information:

Biochemical and Histologic Effect of Dietary Substitution with Solvent Extracted Neem Seed Cake of Albino Rats (wistar strain)

D.B James, D.A Ameh , A.S Agbaji and N. D.G Ibrahim
Corresponding Author:  Dorcas B James 

Key words:  Neem seed, Processd cake, Substitution, Solvent extraction, Albino rats, ,
Vol. 1 , (1): Page No: 1-5
Submitted Accepted Published
2009 June, 06
Abstract:

The performance of 20 albio rats (wistar strain) ages 3 weeks was investigated by feeding neem seed cake (NSC) after treatment with solvents. Group 1 and those of group II and III were fed experimental diets containing water, 75% methanol and 75% ethanol processed neem seed cake respectively as a replacement for soya bean for a period of 28days. Replacement of soya bean by water processed neem seed depressed the growth at the end of 4th week while for the other solvent processing 4th week was a period of stunted growth. There was no significant (p>0.05) difference in the PCV and Hb of animals fed MNSC diet compared to animals fed with standard protein diet. All the animals fed with processed neem seed cakes showed significant (p<0.05) increases in serum albumin compared to standard. Of all the serum marker enzymes determ ined only the level of SGOT for animals fed with ethanol processed neem seed cake was significantly (p<0.05) higher and the histopathology studies revealed fatty degeneration and necrosis of hepatic tissue and glomerular and renal necrosis compared to the standard feed and other solvents treated.
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  Cite this Reference:
D.B James, D.A Ameh , A.S Agbaji and N. D.G Ibrahim, 2009. Biochemical and Histologic Effect of Dietary Substitution with Solvent Extracted Neem Seed Cake of Albino Rats (wistar strain).  International Journal of Animal and Veterinary Advances, 1(1): Page No: 1-5.
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ISSN (Online):  2041-2908
ISSN (Print):   2041-2894
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