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Article Information:
Evaluation of the Effect of Aqueous-methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels of Alloxan Induced Diabetic Wistar Rats
A.O. Okpanachi, A.B. Adelaiye, A.A.U. Dikko, M. Kabiru, A. Mohammed and Y. Tanko
Corresponding Author: okpanachi Omachonu Alfred
Submitted: 2009 August, 18
Accepted: 2009 September, 14
Published: 2010 July, 05 |
Abstract:
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This study was undertaken over a 24 h period to evaluate the hypoglycemic effect of aqueousmethanolic
stem bark extract of Acacia polyacantha on blood glucose levels of alloxan-induced diabetes rats.
Three doses of the extract (100, 200 and 400 mg/kg) were administered p.o. There was a significant decrease
in the blood glucose levels between 8th to 24th h after treatment with the dose of 400 mg/kg when compared
with the control. Also after the 16th h of treatment there was a significant decrease in the blood glucose levels
with the dose of 200 mg/kg when compared to control. As regards to the dose of 100 mg/kg there was no any
significant decrease in the blood glucose levels when compared to control. The preliminary phytochemical
screening revealed the presence of alkaloids,anthraquinones, tannins, flavonoids, steroids and saponins. The
median lethal dose (LD50) in rats was calculated to be 3.807.9 mg/kg body weight. In conclusion the aqueous
methanolic stem bark extract of Acacia polyacantha possess anti-diabetic effect in alloxan- induced in diabetic
rats.
Key words: Acacia polyacantha, hypoglycemic activity, alloxan, diabetes mellitus, phytochemicals, ,
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Cite this Reference:
A.O. Okpanachi, A.B. Adelaiye, A.A.U. Dikko, M. Kabiru, A. Mohammed and Y. Tanko, . Evaluation of the Effect of Aqueous-methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels of Alloxan Induced Diabetic Wistar Rats. International Journal of Animal and Veterinary Advances, (3): Page No: 59-62.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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