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2014 (Vol. 6, Issue: 2)
Article Information:

The Effect of Flunixin Injection on Reproductive Hormones in Male Mice

Iman Kazemi, Mehrdad Modaresi and Akbar Pirestani
Corresponding Author:  Mehrdad Modaresi 

Key words:  Flunixin, FSH, LH, mice, testosterone, ,
Vol. 6 , (2): 74-76
Submitted Accepted Published
November 20, 2013 November 30, 2013 April 20, 2014

Flunixin is an anti inflammatory non steroidal chemical compound which is used as an analgesic and antipyretic drug in veterinary. Considering the frequent use of this drug in recent years this study was conducted to investigate the effects of this drug on pituitary-gonad axis of male mice. Results of this study can be used highly for better use of this drug and saving sexual power of male sex. Five experimental groups with eight male mice in each group were studied as control, Placebo and three treatment groups. Flunixin was injected in 0.5, 1 and 1.5 mg/kg in peritoneum in a twenty-day period. Control group didnít receive any injection and Placebo group received only physiological serum. At the end of twenty days, blood samples were prepared and the amounts of FSH, LH and testosterone hormones were measured. Obtained data were analyzed using SPSS11.5 program. According to results, FSH and LH concentrations were increased significantly (p<0.05) but testosterone was not changed. Results show that flunixin can affect sexual power of male sex by increasing hormones of pituitary-testicle axis.
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  Cite this Reference:
Iman Kazemi, Mehrdad Modaresi and Akbar Pirestani, 2014. The Effect of Flunixin Injection on Reproductive Hormones in Male Mice.  International Journal of Animal and Veterinary Advances, 6(2): 74-76.
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ISSN (Online):  2041-2908
ISSN (Print):   2041-2894
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