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2012 (Vol. 4, Issue: 3)
Article Information:

Anti-Lipidimic and Anti-Hyperglycemic Properties of Methanolic Extract of Grape Seed in Diabetic rats

Zohre Ganjali, Fereshteh Javadian, Jasem Estakhr and Abbas Heidari
Corresponding Author:  Farzaneh Shakeri 

Key words:  Grape seed, blood sugar, lipid profile, insulin, , ,
Vol. 4 , (3): 173-175
Submitted Accepted Published
January 14, 2012 February 17, 2012 June 15, 2012

The aim of this study was to assess the effect of methanolic grape seed extract on the blood glucose and lipid profile in diabetic rats. For this research 30 male adult rats were randomly selected and divided into three groups as nondiabetic control; diabetic control; diabetic rats treated with methanolic extract of grape seed. In diabetic groups, alloxan monohydrate (120 mg/kg) was injected intraperitoneally to develop diabetes. Then the Test group received intraperitoneal injection of methanolic extract of grape seed (100 mg/kg). At last, glucose, cholesterol, triglyceride, HDL, VLDL, LDL and insulin contents of the rats' serum sample were determined. Diabetic rats treated with extract showed a significant decrease in blood glucose level (p<0.05). There was a significant decrease in serum contents of total cholesterol (TC), LDL, VLDL and TG, but a significant increase in insulin level and HDL of extract-treated group was observed in compare with diabetic group (p<0.05). These results show that the methanolic extract of Grape Seed may be effective in the treatment of diabetes. This effect may be due to the presence of flavonoides and antioxidant properties of grape seed.
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  Cite this Reference:
Zohre Ganjali, Fereshteh Javadian, Jasem Estakhr and Abbas Heidari, 2012. Anti-Lipidimic and Anti-Hyperglycemic Properties of Methanolic Extract of Grape Seed in Diabetic rats.  International Journal of Animal and Veterinary Advances, 4(3): 173-175.
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ISSN (Online):  2041-2908
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