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Abstract
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Article Information:
Effect of Intramuscular Injection of Tobramycin on Some Biochemical Parameters in Blood of Sheep
A. El-Magdoub, S.K. Awidat, M. Draid, A. Elgerwi and A. El-Mahmoudy
Corresponding Author: Abdelrazzag Elmagdoub
Submitted: February 09, 2012
Accepted: March 10, 2012
Published: April 20, 2012 |
Abstract:
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The object of the present study was to assess the possible alterations in blood of sheep that may occur
following intramuscular injection of tobramycin. Tobramycin was injected to 10 sheep at a dosage regimen of
5 mg/kg of body weight for 5 successive days. Two types of blood samples (with and without EDTA as an
anticoagulant) were collected from the jugular vein before and after the antibiotic course. Tobramycin
significantly (p<0.05) increased levels of blood urea nitrogen, creatinine, aspartate aminotransferase, alkaline
phosphatase, sodium and calcium. On the other hand, it significantly (p<0.05) decreased serum total bilirubin
level. Other parameters including, erythrocytic count, packed cell volume, hemoglobin, total and differential
leukocytic counts, alanine aminotransferase, G-glutamyltransferse, potassium and phosphorus did not show any
significant difference when compared with those of prior-administration samples. These data suggest that
tobramycin should be used with care in treatment of sheep with renal impairment; its dosage regimen should
be adjusted to avoid its nephrotoxic effect.
Key words: Biochemical parameters, blood, hepatotoxicity, nephrotoxicity, sheep, tobramycin,
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Cite this Reference:
A. El-Magdoub, S.K. Awidat, M. Draid, A. Elgerwi and A. El-Mahmoudy, . Effect of Intramuscular Injection of Tobramycin on Some Biochemical Parameters in Blood of Sheep. International Journal of Animal and Veterinary Advances, (2): 130-134.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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