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    Abstract
2012 (Vol. 4, Issue: 2)
Article Information:

A Study of the Serum Concentrations of Some Hepatic Enzymes in Doses of Aqueous Leaf Extract of Vernonia amygdalina in Rabbits

E.B. Ezenwanne and R.E. Ucheya
Corresponding Author:  E.B. Ezenwanne 

Key words:  Hepatic enzymes, increase, rabbit, serum level, Vernonia amygdalina extract, ,
Vol. 4 , (2): 80-83
Submitted Accepted Published
November 15, 2011 December 27, 2011 April 20, 2012
Abstract:

Healthy adult female rabbits were used to assess possible alterations in the serum levels of some of the enzymes associated with metabolic functions of the liver, in doses of aqueous leaf extract of Vernonia amygdalina. The study was carried out in standard laboratory diet and clean water. Twenty rabbits were placed into four groups of five animals per cage. Three test groups of the rabbits received daily oral doses of 400, 200 and 100 mg/kg of body weight, of the liquid leaf extract of Vernonia amygdalina, respectively, for a total period of three weeks. The control group of five animals were placed on normal laboratory feeds and clean water, and received no treatments with Vernonia amygdalina extract for the same period of three weeks. Weekly assessments of serum levels of two of the key enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), were compared with those of the age and sex matched controls. Evaluation analysis of the collected data was by the studentsít-test taking the value, p≤0.05 as statistically significant. The results revealed a steady dose- dependent increase (p≤0.05) in serum levels of both ALT and AST enzymes, compared with those of the baseline controls values. The observed dose-dependent alterations in the serum levels of these hepatic enzymes ware noted as indicative that Vernonia amygdalina may possess some clearly definable influences or modulating effects on the metabolic functions of the liver in rabbit.
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  Cite this Reference:
E.B. Ezenwanne and R.E. Ucheya, 2012. A Study of the Serum Concentrations of Some Hepatic Enzymes in Doses of Aqueous Leaf Extract of Vernonia amygdalina in Rabbits.  International Journal of Animal and Veterinary Advances, 4(2): 80-83.
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ISSN (Online):  2041-2908
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