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Abstract
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Article Information:
A Study of the Serum Concentrations of Some Hepatic Enzymes in Doses of Aqueous Leaf Extract of Vernonia amygdalina in Rabbits
E.B. Ezenwanne and R.E. Ucheya
Corresponding Author: E.B. Ezenwanne
Submitted: November 15, 2011
Accepted: December 27, 2011
Published: April 20, 2012 |
Abstract:
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Healthy adult female rabbits were used to assess possible alterations in the serum levels of some of
the enzymes associated with metabolic functions of the liver, in doses of aqueous leaf extract of Vernonia
amygdalina. The study was carried out in standard laboratory diet and clean water. Twenty rabbits were placed
into four groups of five animals per cage. Three test groups of the rabbits received daily oral doses of 400, 200
and 100 mg/kg of body weight, of the liquid leaf extract of Vernonia amygdalina, respectively, for a total
period of three weeks. The control group of five animals were placed on normal laboratory feeds and clean
water, and received no treatments with Vernonia amygdalina extract for the same period of three weeks.
Weekly assessments of serum levels of two of the key enzymes, aspartate aminotransferase (AST) and alanine
aminotransferase (ALT), were compared with those of the age and sex matched controls. Evaluation analysis
of the collected data was by the students’t-test taking the value, p≤0.05 as statistically significant. The results
revealed a steady dose- dependent increase (p≤0.05) in serum levels of both ALT and AST enzymes, compared
with those of the baseline controls values. The observed dose-dependent alterations in the serum levels of these
hepatic enzymes ware noted as indicative that Vernonia amygdalina may possess some clearly definable
influences or modulating effects on the metabolic functions of the liver in rabbit.
Key words: Hepatic enzymes, increase, rabbit, serum level, Vernonia amygdalina extract, ,
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Abstract
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Cite this Reference:
E.B. Ezenwanne and R.E. Ucheya, . A Study of the Serum Concentrations of Some Hepatic Enzymes in Doses of Aqueous Leaf Extract of Vernonia amygdalina in Rabbits. International Journal of Animal and Veterinary Advances, (2): 80-83.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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