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Abstract
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Article Information:
Effects of Aqueous and Methanol Extracts of Zingiber officinale on the Haematological Profile in Schistosoma haematobium-Infected Mice
Y. Labe and H.I. Inabo
Corresponding Author: H.I. Inabo
Submitted: 2011 October, 12
Accepted: 2011 November, 23
Published: 2015 February, 15 |
Abstract:
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The aim of the study was to evaluate the immunomodulating effects of aqueous and methanol
extracts of Zingiber officinale on the haematological profile in Schistosoma haematobium - infected mice.The
weight and haematological profiles of Schistosoma haematobium - infected mice were assessed to evaluate the
immunomodulating effects of aqueous and methanolic extracts of Zingiber officinale at post-infection and
post-treatment. There was a non-significant decrease (p>0.05) in the weight of mice in all the groups. However,
there was a significant increase (p<0.05) in the total white blood cell counts, neutrophils and lymphocytes for
group I (S. haematobium - infected mice treated with 9.5 mg/kg aqueous extract of Zingiber officinale). In
group II - (S. haematobium - infected mice treated with 87 mg/kg methanolic extract of Zingiber officinale),
there was significant increase (p<0.05) in the haemoglobin level and white blood cells. Methanolic extract of
Zingiber officinale has better anti-anaemic effect than the aqueous extract of Zingiber officinale. There was
no relationship between the level of eosinophils and the treated mice. No significant change in the
haematological indices was observed in the group which was administered the standard drug- Praziquantel
(PZQ). The immunomodualting effects of aqueous and methanol extracts of Zingiber officinale when compared
to PZQ are promising in immunosuppressed Schistosoma haematobium- infected mice. Fractionation of the
crude extract of Zingiber officinale may further identify the bioactive components required for treatment of
urinary schistosomiasis.
Key words: Haemoglobin, immunomodulation, neutrophils and lymphocytes, Schistosoma haematobium, white blood cells, Zingiber officinale,
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Cite this Reference:
Y. Labe and H.I. Inabo, . Effects of Aqueous and Methanol Extracts of Zingiber officinale on the Haematological Profile in Schistosoma haematobium-Infected Mice. International Journal of Animal and Veterinary Advances, (1): 29-33.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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