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Abstract
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Article Information:
Hypoglycaemic Activity of Globimetulla browni Extracts in Streptozotocin -induced Diabetic Wistar Rats during Dry Season
H.M. Inuwa, V.O. Aina, S. Ibrahim and D.A. Ameh
Corresponding Author: H.M. Inuwa
Submitted: 2011 July, 20
Accepted: 2011 October, 07
Published: 2012 February, 15 |
Abstract:
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Globimetulla browni is a specie of African mistletoe (Lorantheceae) and is hemi-parasitic in nature.
It was studied for ascribed/folkloric antidiabetic properties. Stretozotocin which is well known for its selective
pancreatic β-cell cytotoxicity was used to induce type 1 diabetes in the experimental rat model. Glibenclamide
was used as a standard antidiabetic drug in streptozotocin induced diabetes to compare the efficacy of variety
of hypoglycaemic agents. The extracts from this specie significantly increased the body weights of the albino
rats with the extracts effectively controlling the increase in the glucose levels in the diabetic group of rats which
could be attributed to its antihyperglycemic effects. Further, the antihyperglycemic activities of the extracts was
associated with an increase in plasma insulin level, suggesting an insulinogenic activity of the plant extract.
Key words: Diabetes, extracts, Globimetulla browni, hypoglycaemic, streptozotocin, wistar rats,
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Abstract
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Cite this Reference:
H.M. Inuwa, V.O. Aina, S. Ibrahim and D.A. Ameh, . Hypoglycaemic Activity of Globimetulla browni Extracts in Streptozotocin -induced Diabetic Wistar Rats during Dry Season. International Journal of Animal and Veterinary Advances, (1): 19-21.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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