|
Abstract
|
Article Information:
A Candidate SNP in the Bovine SP110 Gene is not Associated with Susceptibility to Tuberculosis in Cattle
O. Ruiz-Larrañaga, C. Manzano, M. Iriondo, J.M. Garrido, M. Aguirre, P. Vazquez, R.A. Juste and A. Estonba
Corresponding Author: O. Ruiz-Larrañaga
Submitted: 2011 May, 17
Accepted: 2011 July, 02
Published: 2011 December, 25 |
Abstract:
|
The human SP110 nuclear body protein (SP110) gene and the orthologous murine Intracellular
pathogen resistance 1 (Ipr1) have been reported to be related with susceptibility to tuberculosis. In addition,
a recent study reported that SNP c.587A>G (N196S) in the bovine SP110 gene is associated with susceptibility
to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle. The objective of the present study
was to analyze the putative association between SNP c.587A>G in SP110 gene and susceptibility to
Mycobacterium bovis infection in cattle. A total of 158 cows (50 infected and 108 non-infected) from a
multibreed sample were included in the study. Neither SNP c.587A>G alleles nor genotypes showed significant
association with susceptibility to Mycobacterium bovis infection in the analyzed cattle population. Nevertheless,
other SNPs in this gene must be analyzed in order to rule out the implication of SP110 gene in susceptibility
to bovine tuberculosis.
Key words: Bovine tuberculosis, genetic association, single nucleotide polymorphism, SP110 nuclear body protein, , ,
|
|
Abstract
|
PDF
|
HTML |
|
Cite this Reference:
O. Ruiz-Larrañaga, C. Manzano, M. Iriondo, J.M. Garrido, M. Aguirre, P. Vazquez, R.A. Juste and A. Estonba, . A Candidate SNP in the Bovine SP110 Gene is not Associated with Susceptibility to Tuberculosis in Cattle. International Journal of Animal and Veterinary Advances, (6): 407-408.
|
|
|
|
 |
ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
 |
| Information |
|
|
|
|
| Sales & Services |
|
|
|
|
