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    Abstract
2011 (Vol. 3, Issue: 5)
Article Information:

Histological Observations of the Testis of Wistar Rats Following the Oral Administration of Cotecxin (dihyroartemisinin)

T. Murdakai, A.A. Buraimoh and H.O. Kwanashie
Corresponding Author:  Buraimoh Adebayo Adekunle 

Key words:  Cotecxin, histological observations, oral administration, testis, wistar rats, ,
Vol. 3 , (5): 402-406
Submitted Accepted Published
2011 August, 26 2011 September, 25 2011 October, 15
Abstract:

Cotecxin has been reportedly used in the treatment of malaria with high clinical effect and low toxicity. This study therefore, tried to examine the effects of cotecxin on the histology of the testis of wistar rats. A total of twenty four (24) male wistar rats were the subjects used in this experiment. The wistar rats were divided into three groups with each group containing eight (8) rats. Different concentrations of cotecxin were administered orally to the wistar rats which had an average weight of 150 g. Group I is the control group, Group II received 3.42 mg/kg and Group III were given 17.10 mg/Kg. The duration of administration was seven days. After which four (4) rats from each group were sacrificed on the 8th day. The remaining twelve rats were equally sacrificed on the 15th day and immediately fixed in 10% formalin. The tissues were processed and stained in haematoxylin and eosin (H&E). The changes observed on the eighth day in the testis were disarray of the spermatogenic cells and disorientation of the testis. These changes were observed to have been disappearing and normal histological features being restored in those rats sacrificed at the 15th day. It was therefore concluded that cotecxin has negative effect on the histology of the testis during administrations and these effects were reversible some days after stoppage of the administration. This suggests that cotexcin could be safe but Itís prolong usage may be discouraged.
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  Cite this Reference:
T. Murdakai, A.A. Buraimoh and H.O. Kwanashie, 2011. Histological Observations of the Testis of Wistar Rats Following the Oral Administration of Cotecxin (dihyroartemisinin).  International Journal of Animal and Veterinary Advances, 3(5): 402-406.
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