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Abstract
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Article Information:
Effect of Different Concentrations of Bacillus cereus and its Bacteriocin on Some Hematological Indices of Wistar Rats
Victoria Olusola Adetunji and Sarah Chinonyerem Anyanwu
Corresponding Author: Victoria Olusola Adetunji
Submitted: 2011 June, 12
Accepted: 2011 July, 18
Published: 2011 August, 30 |
Abstract:
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Bacillus is an interesting genus to investigate since it produces a diverse array of antimicrobial
peptides representing several different basic chemical structures. The production of bacteriocins or bacteriocinlike
substance has already been described for B. substilis, B. stearothermophilus and other Bacillus sp. The
present study assessed the effects of Bacillus cereus and its bacteriocin at different concentrations on the
hematological parameters of male and female Wistar rats. For the acute intramuscular toxicity test, 10 Wister
rats were randomly divided into five groups of two each. Each group constitutes a male and a female rat. The
first and second group received Bacillus cereus at doses equivalent to 102 and 104 CFU while the third and
fourth groups received the bacteriocin of the bacilli organism at the same concentration. The fifth group was
used as the control and was given distill water. Blood samples were collected for hematology at day 0, 2, 10
and 15. The body weights before and after the experimental period were also noted. Analysis of variance
(ANOVA) was used to determine the degree of significance between the baseline and subsequent days at
p<0.05. There were no pathologic significant hematologic changes in the treated group. However, it was
observed that lower concentration of Bacillus cereus and its bacteriocin is preferred to higher concentration of
the Bacilli organism and its bacteriocin.
Key words: Bacillus cereus, bacteriocin, hematological parameters, rats, toxicity, ,
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Cite this Reference:
Victoria Olusola Adetunji and Sarah Chinonyerem Anyanwu, . Effect of Different Concentrations of Bacillus cereus and its Bacteriocin on Some Hematological Indices of Wistar Rats. International Journal of Animal and Veterinary Advances, (4): 255-260.
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ISSN (Online): 2041-2908
ISSN (Print): 2041-2894 |
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