This study was designed to investigate the significance of varying combination of vitamin A, C and E on lipidemic profile in pregnancy. In a bid to achieve this task, 70 female Wister rats weighing between 250- 300 g were procured and grouped into 2 control groups treated with distilled H₂O and vehicle, tween-80 respectively and three cohorts (I, II and III) with four sub-groups (n = 5). Pregnancy was confirmed on the 6^th day after mating with male Wister rats, after which group I received a combination of vitamin A and C, group II- vitamin A and E and group III- vitamin C and E respectively for 11 days. Results revealed a significant (p<0.05) increase in HDL-C in the entire combination group, which was dose dependent. This was more prominent in group II (vit A + E). Although, there were reductions in serum cholesterol (CHO), serum triglyceride (TRI) and LDL-C levels, this was not significant (p>0.05). In conclusion, the synergetic potential of antioxidant vitamin combination appears beneficial in the management of pregnancy related hyperlipedemic states.