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2011 (Vol. 3, Issue: 2)
Article Information:

Synergistic Effects of Antioxidant Vitamins on Lipid Profile in Pregnancy

O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, A. Aigbiremolen, E.O. Nwoke and U. Akpamu
Corresponding Author:  Osede Ignis Iribhogbe 

Key words:  Antioxidants, hyperlipidemia, pregnancy, synergistic effect, vitamins, ,
Vol. 3 , (2): 104-109
Submitted Accepted Published
2010 October, 11 2010 November, 15 2011 March, 05
Abstract:

This study was designed to investigate the significance of varying combination of vitamin A, C and E on lipidemic profile in pregnancy. In a bid to achieve this task, 70 female Wister rats weighing between 250- 300 g were procured and grouped into 2 control groups treated with distilled H2O and vehicle, tween-80 respectively and three cohorts (I, II and III) with four sub-groups (n = 5). Pregnancy was confirmed on the 6th day after mating with male Wister rats, after which group I received a combination of vitamin A and C, group II- vitamin A and E and group III- vitamin C and E respectively for 11 days. Results revealed a significant (p<0.05) increase in HDL-C in the entire combination group, which was dose dependent. This was more prominent in group II (vit A + E). Although, there were reductions in serum cholesterol (CHO), serum triglyceride (TRI) and LDL-C levels, this was not significant (p>0.05). In conclusion, the synergetic potential of antioxidant vitamin combination appears beneficial in the management of pregnancy related hyperlipedemic states.
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  Cite this Reference:
O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, A. Aigbiremolen, E.O. Nwoke and U. Akpamu, 2011. Synergistic Effects of Antioxidant Vitamins on Lipid Profile in Pregnancy.  Current Research Journal of Biological Sciences, 3(2): 104-109.
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ISSN (Online):  2041-0778
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