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Abstract
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Article Information:
Levels of Parasitaemia and Changes in Some Liver Enzymes among Malarial Infected Patients in Edo-Delta Region of Nigeria
I. Onyesom and N. Onyemakonor
Corresponding Author: Innocent Onyesom
Submitted: 2010 May, 25
Accepted: 2010 October, 06
Published: 2011 March, 05 |
Abstract:
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Hepatic dysfunction is a common complication in malaria and this could be characterized by increase
in liver enzyme activities. The activities of some liver enzymes: Serum aspartate transaminase (AST), alanine
transaminase (ALT) and alkaline phosphatase (ALP) were assayed in 60 individuals comprising both males and
females, age between 10-60 years. Malarial parasite status and densities were also determined and correlated
with the enzyme values Thirty (30) individuals presenting with acute uncomplicated falciparum malarial
infection were selected as test subjects and 30 sex and age-matched apparently healthy individuals without the
infection were included as control group. Malarial parasite count was by the Giemsa stain and the liver
enzymes were assayed by standard methods. Results show that there was a positive relationship between the
enzyme activities and the level of parasitaemia (p<0.05). Changes in the AST (33.4±16.4 IU/L), ALT
(21.3±14.4 IU/L) and ALP (87.4±25.6 IU/L) activities for the infected subjects were higher compared with their
non-infected counterparts (AST: 22.3±7.4 IU/L, ALT: 15.2±5.8 IU/L, ALP: 56.4±16.7 IU/L). Evidence
indicates a measure of compromise in hepatic integrity and this bears a positive correlation with the levels of
parasitaemia. Post-treatment values should be obtained and compared in order to provide a detailed
understanding for improved treatment.
Key words: ALT, AST, hepatic dysfunction, liver enzymes, Malaria, P. falciparum,
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Abstract
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Cite this Reference:
I. Onyesom and N. Onyemakonor, . Levels of Parasitaemia and Changes in Some Liver Enzymes among Malarial Infected Patients in Edo-Delta Region of Nigeria. Current Research Journal of Biological Sciences, (2): 78-81.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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