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Article Information:
Antioxidant Activities of Allium sativum on some Biochemical parameters following Ethanol Induced Lesion in the Gastric Mucosa of Adult Male Wistar Rats
M.O. Buhari, Mesole S.B, Olusakin Jimmy, A.A. Okesina and A.A. Mohammed
Corresponding Author: Buhari Muhammad Olanrewaju
Submitted: July 24, 2014
Accepted: September 13, 2014
Published: July 20, 2015 |
Abstract:
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This study was carried out to investigate, the protective potential of Allium sativum on the stomach following ethanol-induced mucosal lesions in Adult male wistar rats (Rattus novergicus). Twenty four Adult male Wistar rats were used in the study and divided randomly into 3 groups (8 animals in each); Group A received orally, Phosphate Buffered Saline (PBS) and served as control; groups B and C received 1.0 mL of 35% ethanol orally every 24 h and group C received freshly prepared Garlic Homogenate (FGH) (300 mg/kg/body weight) once daily one hour prior to ethanol administration. The study was for 21 days after which the animals were sacrificed following cervical dislocation and the stomach being the organ of study were excised. The excised stomach was homogenised in 5% sucrose solution for biochemical studies and there was significant increase in the level of GSH-Px of FGH treated group when compared to those treated with ethanol only. Marked increase in the level of G-6-PDH and TBARS in ethanol treated group was observed compared to FGH treated and the control groups.
Key words: Allium sativum, glucose-6-phosphate dehydrogenase (G-6-PDH), gluthathion peroxidise (GSH-Px), Rattus novergicus, Stomach, thiobabituric acid (TBARS),
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Cite this Reference:
M.O. Buhari, Mesole S.B, Olusakin Jimmy, A.A. Okesina and A.A. Mohammed, . Antioxidant Activities of Allium sativum on some Biochemical parameters following Ethanol Induced Lesion in the Gastric Mucosa of Adult Male Wistar Rats. Current Research Journal of Biological Sciences, (3): 43-46.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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