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Article Information:
Role 14-3-3 Protein in Regulation Some Cellular Processes
Nagam Khudhair, Yu Cuiping, Ahmed Khalid and Xuejun Gao
Corresponding Author: Xuejun Gao
Submitted: May 10, 2014
Accepted: July 01, 2014
Published: September 20, 2014 |
Abstract:
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The aim of this study to review an overview of the current information on the structure of proteins 14-3-3 and their complexes, in addition to that it provides insights into the mechanisms of their functions. The 14-3-3 proteins are from families maintain regulatory molecules expressed in all eukaryotic cells. It was discovered before thirty years, it is attributes of 14-3-3 proteins are able to connect a large number of signalling proteins are functionally diverse, including kinases, phosphatases and transmembrane receptors. 14-3-3 proteins play an important role in a variety of vital regulatory processes, such as protein regulation, apoptotic cell death and cell cycle control. In this review, we discussed the structural basis of 14-3-3 proteins, common structural features of their complexes, Phosphorylation, Cell cycle and Apoptosis.
Key words: 14-3-3 Protein , apoptosis, cell cycle, phosphorylation, structure, ,
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Cite this Reference:
Nagam Khudhair, Yu Cuiping, Ahmed Khalid and Xuejun Gao, . Role 14-3-3 Protein in Regulation Some Cellular Processes. Current Research Journal of Biological Sciences, (5): 197-204.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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