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2014 (Vol. 6, Issue: 1)
Article Information:

Effect of Vitamins C & E on Aspirin Induced Gastric Mucosal Damage and Oxidative Stress

F.A. Dawud, M.A. Mabrouk, A. Mohammed and I.A. Umar
Corresponding Author:  F.A. Dawud 

Key words:  Acetylsalicylic acid, antioxidants, free radicals, gastric ulcer, , ,
Vol. 6 , (1): 36-41
Submitted Accepted Published
October 26, 2013 November 07, 2013 January 20, 2014
Abstract:

The effects of Vitamins C & E on Aspirin - induced gastric mucosal damage on gastric ulcer parameters and stomach oxidative stress markers were determined in acute and sub-acute studies in Wistar rats. Aspirin produced a significant (p<0.05) increase in gastric ulcer score in both studies. Vitamins C & E conferred protection in acute and sub-acute studies with preventive indices of 54 and 60% respectively. Histologically the gastric mucosa of animals in the sub-acute study showed a severe necrosis of the epithelial cells than observed in the acute study. Acute aspirin administration did not increase the stomach tissue Malondialdehyde (MDA) but sub-acute administration significantly (p<0.05) increased MDA, while vitamins C & E caused a significant (p<0.05) decrease below the level seen in normal controls. Aspirin in both studies significantly decreased Catalase activity. While acute aspirin exposure had no effect on Superoxide Dismutase (SOD) activity, sub-acute exposure raised it significantly (p<0.05). Administration of Vitamins C and E significantly increased SOD activity only in the acute study. Aspirin significantly decreased reduced Glutathione (GSH) in both studies and was reversed by Vitamin C and E. The level of GSH reductase (GSHRD) in the acute study was significantly decreased by aspirin but sub-acutely and prior treatment with vitamins C and E had no significant effect. Combine administration of vitamins C & E prior to intake of aspirin significantly prevented aspirin-induced gastric ulceration with decrease in some oxidative stress markers.
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  Cite this Reference:
F.A. Dawud, M.A. Mabrouk, A. Mohammed and I.A. Umar, 2014. Effect of Vitamins C & E on Aspirin Induced Gastric Mucosal Damage and Oxidative Stress.  Current Research Journal of Biological Sciences, 6(1): 36-41.
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ISSN (Online):  2041-0778
ISSN (Print):   2041-076X
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