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Abstract
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Article Information:
Hypocholestrolemic and Antioxidant Activities of Dikanut (Irvingia gabonensis) Supplemented Diet in Abino Rats
Friday O. Uhegbu, Kingsley C. Nwoku and Victor C. Ude
Corresponding Author: Friday O. Uhegbu
Submitted: October 31, 2012
Accepted: December 21, 2012
Published: May 20, 2013 |
Abstract:
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Hypocholesterolemic and Antioxidant activities of Dikanut (Irvingia gabonensis) supplemented diet in Abino rats was investigated. Albino rats (males) were fed diets `supplemented with 10, 20 and 30%, respectively dikanut for 14 days. Results showed significant (p<0.05) reductions in cholesterol levels compared to control; 1.43±0.08 to 0.88±0.10 mg/mL in the test animals. Lipid peroxidation levels also decreased significantly (p<0.05) from 6.56±0.23 mg/mL for control to 4.16±0.48 mg/mL for the test animals, while antioxidant enzymes (SOD and Catalase) levels increased significantly (p<0.05) compared to control, 21.30±3.28 to 28.72±3.68 and 2.26±0.05 to 2.95±0.11 U/L, respectively. Glutathione peroxidase level also showed significant (p<0.05) reductions from 3.82±0.41 U/L for control to 3.06±0.62 U/L in the test animals. The elicitation of these effects by the dikanut supplemented diet is a reflection of its hypocholesterolemic and antioxidative properties and could be of nutritional and clinical importance to persons at risk of cardiovascular disease.
Key words: Cardiovascular disorders, cholesterol, free radicals, lipid, oxidative stress, ,
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Cite this Reference:
Friday O. Uhegbu, Kingsley C. Nwoku and Victor C. Ude, . Hypocholestrolemic and Antioxidant Activities of Dikanut (Irvingia gabonensis) Supplemented Diet in Abino Rats. Current Research Journal of Biological Sciences, (3): 104-108.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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