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Abstract
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Article Information:
Effects of Saponin from Solanum anguivi Lam. Fruit on Heart and Kidney Superoxide Dismutase, Catalase and Malondialdehyde in Rat
O.O. Elekofehinti, I.G. Adanlawo, A. Fakoya, J.A. Saliu and S.A. Sodehinde
Corresponding Author: Elekofehinti Olusola Olalekan
Submitted: May 22, 2012
Accepted: June 06, 2012
Published: July 10, 2012 |
Abstract:
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Reactive Oxygen Species (ROS) are generated via normal metabolic processes or as the products
of exogenous insults. They are capable of damaging essential biomolecules and accelerating cancer,
cardiovascular diseases and neurodegenerative diseases. In this study, the effect saponin from Solanum
anguivi (SAS) fruits on Superoxide Dismutase (SOD), catalase (CAT) and Lipid Peroxidation (LPO) in the
homogenates of the hearts and kidney was evaluated. Thirty six male Wister rats of average weight125±12
g were divided into six groups of six animals each. Five treated groups received a daily dose of saponin at
20 40 60 80 and 100 mg/kg, respectively, while distilled water was administered to the control group
for 3 weeks. Solanum anguivi saponin significantly increased (p<0.05) both catalase and SOD activities in
the heart, There was also corresponding increase in activities of both enzymes in the kidney but was not
significant. MDA concentration was reduced significantly (p<0.05) in both tissues. SAS exhibit both
antioxidant and antiperoxidative properties. Saponin from Solanum anguivi could therefore be employed as
sources of natural antioxidant boosters and for the treatment of some oxidative stress disorders in which
free radicals are implicated.
Key words: Antioxidant, antiperoxidative, heart, kidney, oxidative stress, ,
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Abstract
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Cite this Reference:
O.O. Elekofehinti, I.G. Adanlawo, A. Fakoya, J.A. Saliu and S.A. Sodehinde, . Effects of Saponin from Solanum anguivi Lam. Fruit on Heart and Kidney Superoxide Dismutase, Catalase and Malondialdehyde in Rat. Current Research Journal of Biological Sciences, (4): 530-533.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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