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2012 (Vol. 4, Issue: 3)
Article Information:

Association between Haptoglobin Polymorphism and DNA Damage in Type 2 Diabetes

Marghoob Hasan, Mohammad Al zohairy and Abdelmarouf Mohieldein
Corresponding Author:  Marghoob Hasan 

Key words:  Antioxidant, AP site counting, DNA damage, haptoglobin phenotypes, oxidative stress, type 2,
Vol. 4 , (3): 284-289
Submitted Accepted Published
January 10, 2012 February 09, 2012 April 05, 2012
Abstract:

In the present study we aimed to estimate the Oxidative DNA damage in Type 2 diabetic patients in different haptoglobin polymorphism. Type 2 diabetes is associated with imbalance of antioxidant defense mechanism, causes alteration in various biomolecules, including DNA. The oxidative DNA damage and its repair is very crucial in diabetes; the defect in the repair process may lead to cancer among diabetics. Haptoglobin (Hp) is a polymorphic glycoprotein provides antioxidant function against heam- driven oxidative stress and has strong association with diabetes and its complication. We investigated the DNA damage quantification of lymphocytes by AP site (Apurine/Apyrimidine site) counting and that correlated with Hp polymorphism among type 2 diabetics. The Hp1-1 phenotype had the least DNA damage than HP 2-1 & HP 2-2; this indicates that Hp alleles differ in their protective effects against oxidative damage, and HP 1-1 was the most protective.
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  Cite this Reference:
Marghoob Hasan, Mohammad Al zohairy and Abdelmarouf Mohieldein, 2012. Association between Haptoglobin Polymorphism and DNA Damage in Type 2 Diabetes.  Current Research Journal of Biological Sciences, 4(3): 284-289.
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ISSN (Online):  2041-0778
ISSN (Print):   2041-076X
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