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    Abstract
2012 (Vol. 4, Issue: 2)
Article Information:

Total Lipid Profile, Faecal Cholesterol, very Low Density Lipoprotein Cholesterol (VLDL-C), Atherogenic Index (A.I) and Percent Atherosclerosis with Aqueous Fruit Extract of Solanum macrocarpum in Chronic Triton-Induced Hyperlipidemic Albino Rats

Sodipo O. Adebola, Abdulrahman F. Inna and Sandabe U. Kyari
Corresponding Author:  O.A. Sodipo 

Key words:  Atherogenic index, faecal-cholesterol, percent atherosclerosis, Solanum macrocarpum, total lipid profile, VLDL-cholesterol,
Vol. 4 , (2): 206-214
Submitted Accepted Published
2011 November, 28 2011 December, 23 2012 March, 10
Abstract:

Studies were undertaken to investigate the effect of the aqueous fruit extract of Solanum macrocarpum on the total lipid profile [total cholesterol, triglyceride, high density lipoprotein-cholesterol (LDL-C) and low density liprotein cholesterol (LDL-C)], faecal cholesterol, very low density lipoproteincholesterol (VLDL-C), atherogenic index (A.I) and percent atherosclerosis on chronic titron-induced hyperlipidemic rats. The increase in HDL-C was dose-dependent and statistically significant (p<0.05) at both 24 and 72 h. There was no change (p>0.05) with increase in extract dose for both total cholesterol and triglycerides throughout the period of study while the decrease in LDL-C was significant (p<0.05) at 72h. The increase in faecal cholesterol with increase extract dose was significant (p<0.05) at 48 and 72h of study. The VLDL-C and percent atherosclerosis reduced with increase in extract dose. The decrease in VLDL-C was only significant (p<0.05) at 72h whilst that for percent atherosclerosis was significant (p<0.05) at both 48 and 72h. There was no change in A.I. (p>0.05). The results shows that the plant may be capable of reducing circulating lipids in chronic triton-induced hyperlipidemic rats probably by reducing absorption of lipids, thus, reducing hyperlipidemia. At the same time, the aqueous fruit extract probably has the potential to reduce the risk of development of heart diseases since VLDL-C has been shown to be beneficial and indicative of a lower risk of coronary heart diseases. Also, a reduction in percent atherosclerosis is desirable as this implies that atherosclerosis is reduced.
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  Cite this Reference:
Sodipo O. Adebola, Abdulrahman F. Inna and Sandabe U. Kyari, 2012. Total Lipid Profile, Faecal Cholesterol, very Low Density Lipoprotein Cholesterol (VLDL-C), Atherogenic Index (A.I) and Percent Atherosclerosis with Aqueous Fruit Extract of Solanum macrocarpum in Chronic Triton-Induced Hyperlipidemic Albino Rats.  Current Research Journal of Biological Sciences, 4(2): 206-214.
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