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2012 (Vol. 4, Issue: 2)
Article Information:

Ameliorative Effects of Vitamin C and Zinc in Alloxan-induced Diabetes and Oxidative Stress in Wistar Rats

F.A. Dawud, E.D. Eze, A.A. Ardja, A.S. Isa, A. Jimoh, M. Bashiru and I.S. Malgwi
Corresponding Author:  F.A. Dawud 

Key words:  Alloxan, diabetes mellitus, malondialdehyde, oxidative stress, vitamin C, zinc,
Vol. 4 , (2): 123-129
Submitted Accepted Published
2011 September, 29 2011 November, 04 2012 March, 10
Abstract:

This study was undertaken to evaluate the ameliorative effects of vitamin C and zinc on blood glucose levels and lipid peroxidation in Alloxan-induced diabetic Wistar rats. Diabetes was induced in animals by intraperitoneal injection of Alloxan monohydrate (150 mg/kg b w). Diabetic rats were randomly divided into three groups (n = 5): Rats in group I were given 1ml of distilled water and served as the control. Rats in group II and group III were administered 100 50 mg/kg b w of vitamin C and zinc respectively. The regimens were given once daily for seven days. Blood samples collected from the animals at the end of the treatment period and assayed for malonaldehyde (MDA) as index of lipid peroxidation. The study showed that there was a significant (p<0.05) decrease in the blood glucose levels of 206.4033.71, 115.8014.75, 204.2055.93 and 125.8025.44, 118.09.55, 123.6031.71, with Vitamin C 100 mg/kg and zinc 50 mg/kg respectively when compared to control group. Alloxan induced group showed an increased concentration of Malondialdehyde (MDA) of 3.160.98. However, there was a significant reduction (p<0.05) in Malondialdehyde concentration in the group that received 50 mg/kg b w of zinc, while no significant change (p>0.05) was observed in the group that were administered 100 mg/kg b w of vitamin C when compared to the diabetic control group. The present study has shown that vitamin C and zinc had a beneficial effect on Alloxan induced hyperglycemia and oxidative stress as evidenced by decreased malondialdehyde (MDA) concentration.
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  Cite this Reference:
F.A. Dawud, E.D. Eze, A.A. Ardja, A.S. Isa, A. Jimoh, M. Bashiru and I.S. Malgwi, 2012. Ameliorative Effects of Vitamin C and Zinc in Alloxan-induced Diabetes and Oxidative Stress in Wistar Rats.  Current Research Journal of Biological Sciences, 4(2): 123-129.
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