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Abstract
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Article Information:
Effects of Oral Administration of Aluminium Chloride on the Histology of the Hippocampus of Wistar Rats
A.A. Buraimoh, S.A. Ojo, J.O. Hambolu and S.S. Adebisi
Corresponding Author: A.A. Buraimoh
Submitted: 2011 July, 17
Accepted: 2011 August, 30
Published: 2011 September, 10 |
Abstract:
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The study of the effects of oral administration of aluminium chloride on the Hippocampus of wistar
rats was designed in order to ascertain whether the small daily amount of aluminium that gain access to the
body produce any damage to the hippocampus. This investigation was carried out using 50 female adult wistar
rats.The animals were divided into five groups; 10 rats per group (cage). Stock solution of aluminium chloride
was prepared (2 g/L or 2 mg/mL). Different concentrations of aluminium were administered to different groups
orally. Group I was control, while Groups II-V were given 0.4, 1, 2, and 3 mg, respectively per each rat with
an average weight of between 150-200 g for duration of twelve (12) weeks. The animals were humanly
sacrificed using chloroform and then the brain tissues were fixed immediately in Bouin’s fluid. The brain
sections (hippocampus) were processed through the routine tissue processor. The stained samples were
examined by means of light microscope for histological changes. Histological examinations showed clumpy
of cell neurons, or reduced pyramidal cells and scant,y neurofibrillary tangle which was an indication of
neurodegeneration in the treated groups when compared to the control. It was however, concluded that the oral
administration of aluminium chloride could induce brain damage which may impair memory and learning as
seen in Alzheimer disease.
Key words: Aluminium chloride, effects, hippocampus, oral administration, wistar rats, ,
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Cite this Reference:
A.A. Buraimoh, S.A. Ojo, J.O. Hambolu and S.S. Adebisi, . Effects of Oral Administration of Aluminium Chloride on the Histology of the Hippocampus of Wistar Rats. Current Research Journal of Biological Sciences, (5): 509-515.
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ISSN (Online): 2041-0778
ISSN (Print): 2041-076X |
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