In order to evaluate the protective effect of Scoparia dulcis L. (Scrophulariaceae), a medicinal plant known to have medico-magic power, different extracts were prepared by successive extraction with hexane (HE), chloroform (CE) and methanol (ME) and by a soaking in acetone (80%). These extracts were checked for their protective role against neuroinflammation and erythrocytes haemolysis. They exhibited a significant neuroprotective effect on both brain neuronal cells and neurotransmitter enzyme as acetylcholinesterase. By their cytoprotective ability the extracts prevented rat erythrocytes haemolysis between 56% and 83% at 300 :g/mL. These observed protective effects were related to the extracts antioxidant components.