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2011 (Vol. 2, Issue: 1)
Article Information:

Effects of Antioxidant Vitamin Combination on Electrolyte Status in Pregnancy

O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, U. Akpamu, E.O. Nwoke and A. Aigbiremolen
Corresponding Author:  Osede Ignis Iribhogbe 

Key words:  Antioxidants, bi-combination, electrolytes, hypertension, pregnancy, synergistic, vitamins
Vol. 2 , (1): 21-26
Submitted Accepted Published
2010 December, 09 2011 January, 03 2011 February, 10
Abstract:

It is a known fact that hypertension is associated with pregnancy. Several studies have reported a link between hypertension and a shift in serum electrolyte concentration. This study is designed to investigate the effect of antioxidant vitamin A, C and E bi- combination on electrolyte status in pregnancy. In a bid to investigate the above objective, varying combination of antioxidant vitamin A, C and E were administered to 70 pregnant Wister albino rats. These were assigned into two control groups treated with distilled H2O and vehicle- tween-80 respectively and three cohorts (I, II and III) with four sub-groups each (n = 5). Beginning from the 7th day, test group I received a varying dose combination of vitamin A+C, group II vitamin A+E, and group III vitamin C+E respectively for 11 days. Results revealed a non significant reduction (p>0.05) in serum Na+ and Ca2+, and a significant change p<0.05) in serum Cl- and K+ following Vit A+C administration when compared with control. The group treated with Vit A+E combination presented a non significant change in serum Na+, Cl-, K+ and Ca2+ level. Vit C+E treated group presented a significant reduction (p<0.05) in serum Na+, K+ and Ca2+ with no alteration in serum Cl-. In conclusion, antioxidant vitamin A, C and E bi-combination ameliorates the reported high Na+ concentration in pregnancy and may be of significance as adjuvants in the management of hypertension in pregnancy. However, the importance of further research cannot be overemphasized.
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  Cite this Reference:
O.I. Iribhogbe, J.E. Emordi, B.O. Idonije, U. Akpamu, E.O. Nwoke and A. Aigbiremolen, 2011. Effects of Antioxidant Vitamin Combination on Electrolyte Status in Pregnancy.  British Journal of Pharmacology and Toxicology, 2(1): 21-26.
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