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Abstract
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Article Information:
Synthesis, Spectroscopic and Antimicrobial Studies of Transition Metal Complexes of N-Amino Quinolone Derivatives
R.I.H. AL-Bayati, F.R. Mahdi and A.A.H. Al-Amiery
Corresponding Author: A.A.H. Alamiery
Submitted: 2010 October, 30
Accepted: 2010 December, 02
Published: 2011 February, 10 |
Abstract:
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In Iraq like most third world countries, attempts to discovered a new antibiotic drugs derived from
coumarin and its metal complexes moreover develop the branch of applied in organic chemistry. Novel
transition metal(II) complexes, [M(L1)2Cl2] and [M(L2)2Cl2], were synthesized from the reaction of MCl2.nH2O
(M = Co, Ni, Cu) with (Z)-1-(1-(1H-indol-3-yl)ethylideneamino)quinolin-2(1H)-one (L1) or (E)-1-(2-
hydroxybenzylideneamino)quinolin-2(1H)-one (L2). The ligands were obtained from coumarin. N-amino
quinoline-2-one (2) has been synthesized by the reflux of coumarin (1) with hydrazine hydrate in ethanol for
12 h. The azomethines (L1, L2) were prepared from the corresponding aryl carbonyls. The synthesized
compounds were and characterized by element chemical analysis, molar conductance, magnetic susceptibility
measurements, and spectral (electronic, and FT-IR) studies. The IR spectral data suggest the involvement of
sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an
octahedral geometry has been assigned for all complexes. The free ligands and its metal complexes have been
tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.
Key words: Coumarin, quinoline, transition metal (II) complex, , , ,
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Abstract
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Cite this Reference:
R.I.H. AL-Bayati, F.R. Mahdi and A.A.H. Al-Amiery, . Synthesis, Spectroscopic and Antimicrobial Studies of Transition Metal Complexes of N-Amino Quinolone Derivatives. British Journal of Pharmacology and Toxicology, (1): 5-11.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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