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Abstract
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Article Information:
Analgesic, Anti-Inflammatory and Antipyretic Potential of the Stem Bark Extract of Stachytarpheta indica
G.C. Akuodor, A.D. Essien, P.M. Udia, E. David-Oku, K.C. Chilaka, E.C. Asika and S.K. Nwadum
Corresponding Author: G.C. Akuodor
Submitted: October 29, 2014
Accepted: December 27, 2014
Published: February 20, 2015 |
Abstract:
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Aim of study:Stachytarpheta indica is used as herbal remedy for pains in Nigeria. Methods: To validate this claim, the analgesic, anti-inflammatory and antipyretic effects of the stem bark extract were examined in mice and rats by using acetic acid-induced writhing, tail immersion, xylene and egg albumin-induced paw oedema. While yeast and amphetamine induced pyrexia were used to study antipyretic activity in rats. LD50 of the stem bark extract was carried out to determine its safety. Results: The methanol stem bark extract of Stachytarpheta indica showed significant (p<0.05) dose dependent effect in the parameters assayed. The activity of the extract was comparable to acetylsalicylic acid and morphine respectively. The acute toxicity test was greater than 5000 mg/kg. Conclusions: It may be possible that the methanol stem bark extract of Stachytarpheta indica contains biologically active substances with potential value for the treatment of painful and feverish conditions.
Key words: Herbal medicine, inflammation, nociception, pyrexia, rats, Stachytarpheta indica,
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Cite this Reference:
G.C. Akuodor, A.D. Essien, P.M. Udia, E. David-Oku, K.C. Chilaka, E.C. Asika and S.K. Nwadum , . Analgesic, Anti-Inflammatory and Antipyretic Potential of the Stem Bark Extract of Stachytarpheta indica. British Journal of Pharmacology and Toxicology, (1): 16-21.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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