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2010 (Vol. 1, Issue: 1)
Article Information:

In vitro Susceptibility Pattern and Distribution of Aspergillus spp. in Hospitalized Patients with Chronic Pulmonary Infection

Kumar Saurav and K. Kannabiran
Corresponding Author:  Kumar Saurav 

Key words:  Aspergillosis, immunocompromised patients, multidrug résistance, pulmonary infection, , ,
Vol. 1 , (1): Page No: 45-49
Submitted Accepted Published
2010 May, 20 2010 June, 01 2010 June, 20
Abstract:

Aspergillosis is considered as common fungal infection but often seen in immunocompromised patients due to chronic pulmonary infection and other invasive fungal diseases. A. fumigatus, the most pathogenic species are responsible for about 90% of all invasive aspergillosis. Though, current treatments are effective but leads to the emergence of resistant strains to commercially available drugs. In the present study sputum samples from different groups of immunocompromised patients was used for the isolation of Aspergillus species and screened for multidrug résistance against commercially available drugs such as itraconazole, fluconazole, ketoconazole and amphotericin B. We have isolated 204 Aspergillus spp. from different group of immunocompromised patients. A. fumigatus was the predominant Aspergillus spp (43%) followed by A. niger (33%) and others are 24%. Screening of susceptibility pattern of the clinical isolates against antifungal drugs revealed that A. niger was resistant to fluconazole (MIC$64 mg/L) and itraconazole (MIC$32 mg/L) followed by A. fumigatus showed resistance to itraconazole (MIC$32 mg/L).
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  Cite this Reference:
Kumar Saurav and K. Kannabiran, 2010. In vitro Susceptibility Pattern and Distribution of Aspergillus spp. in Hospitalized Patients with Chronic Pulmonary Infection.  British Journal of Pharmacology and Toxicology, 1(1): Page No: 45-49.
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ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
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