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Abstract
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Article Information:
Protective Effect of Penta-acetyl Geniposide on Acute Liver Injury Induced By D-galactosamine in Mice
Hong Zhang, Tianlu Shi, Jing Wang, Rong Li and Wenjian Tang
Corresponding Author: Tianlu Shi
Submitted: August 24, 2013
Accepted: September 03, 2013
Published: December 25, 2013 |
Abstract:
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Penta-acetyl geniposide ((Ac)5 GP), an herbal derivative prepared from Gardenia Fructus geniposide, decreased the DNA damage and hepatocarcinogenesis induced by aflatoxin B1 1 (AFB1). The present study was carried out to further evaluate the protective effect of (Ac)5 GP on liver injury induced by D-galactosamine (D-GalN). D-GalN (400 mg/kg) was given to mice by intraperitoneal injection, while (Ac)5 GP were orally administered by gastric gavage. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) in serum and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) in hepatic tissue. Hepatic histological structure was observed under light microscopy. The features of acute liver injury were observed in D-GalN-treated mice. (Ac)5 GP, similar to silymarin, decreased the elevated serum levels of ALT, AST and MDA and increased the reduced activities of SOD and GSH-Px induced by D-GalN. (Ac)5 GP was also showed to be more effective than GP in reversing these abnormal changes and the levels of (Ac)5GP on MDA and SOD showed a dose-effect relationship. These biochemical observations were also supplemented by histopathological observations of the liver sections. It was concluded from the results that (Ac)5 GP can produce protective effect on acute liver injury induced by D-GalN via an antioxidative mechanism. Therefore,(Ac)5 may be developed as an efficient hepato-protective agent.
Key words: Antioxidative effect, D-galactosamine, gardenia, liver injury, penta-acetyl geniposide, ,
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Cite this Reference:
Hong Zhang, Tianlu Shi, Jing Wang, Rong Li and Wenjian Tang , . Protective Effect of Penta-acetyl Geniposide on Acute Liver Injury Induced By D-galactosamine in Mice. British Journal of Pharmacology and Toxicology, (6): 256-261.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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