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Abstract
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Article Information:
Effect of Light and Storage Time on Vitamin E in Pharmaceutical Products
Pham Phuoc Nhan and Nguyen Kim Hoa
Corresponding Author: Pham Phuoc Nhan
Submitted: June 11, 2012
Accepted: June 25, 2013
Published: October 25, 2013 |
Abstract:
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Vitamin E is an important oxidant for both plant and animal and a lipid soluble vitamin which occurs naturally in edible plant oils and able to be synthesized by oxygenic bacteria. Besides, cooking oils and edible oil containing seeds, human can intake vitamin E via pharmaceutical products. With simply spectral method, vitamin E contents in tablets were quantified easily during storage. Vitamin E levels in medical products sold on Vietnamese market varied among producers ranging from 15 mg up to about 360 mg/tablet. Vitamin E in eight selected products was degraded gradually with prolonged storage time but much more rapidly in scatter light exposure condition than in the dark. The more vitamin E in the tablets, the quicker degradation occurred. Tablets exposed to natural sun light or UV source depleted vitamin E significantly within 5 h, approximately 50% for both lighted conditions. There was a relatively high tight correlation (R2 = 0.8266) between tablet price and its vitamin E content. Customer should buy the higher price products rather than the cheaper ones to get sufficient amount of vitamin E. Pharmaceutical vitamin E products should be used up soon after being bought or kept away any light sources.
Key words: &alpha-tocopherol, dark, tablet, UV light, , ,
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Cite this Reference:
Pham Phuoc Nhan and Nguyen Kim Hoa, . Effect of Light and Storage Time on Vitamin E in Pharmaceutical Products. British Journal of Pharmacology and Toxicology, (5): 176-180.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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