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2013 (Vol. 4, Issue: 5)
Article Information:

Effect of Light and Storage Time on Vitamin E in Pharmaceutical Products

Pham Phuoc Nhan and Nguyen Kim Hoa
Corresponding Author:  Pham Phuoc Nhan 

Key words:  &alpha-tocopherol, dark, tablet, UV light, , ,
Vol. 4 , (5): 176-180
Submitted Accepted Published
June 11, 2012 June 25, 2013 October 25, 2013
Abstract:

Vitamin E is an important oxidant for both plant and animal and a lipid soluble vitamin which occurs naturally in edible plant oils and able to be synthesized by oxygenic bacteria. Besides, cooking oils and edible oil containing seeds, human can intake vitamin E via pharmaceutical products. With simply spectral method, vitamin E contents in tablets were quantified easily during storage. Vitamin E levels in medical products sold on Vietnamese market varied among producers ranging from 15 mg up to about 360 mg/tablet. Vitamin E in eight selected products was degraded gradually with prolonged storage time but much more rapidly in scatter light exposure condition than in the dark. The more vitamin E in the tablets, the quicker degradation occurred. Tablets exposed to natural sun light or UV source depleted vitamin E significantly within 5 h, approximately 50% for both lighted conditions. There was a relatively high tight correlation (R2 = 0.8266) between tablet price and its vitamin E content. Customer should buy the higher price products rather than the cheaper ones to get sufficient amount of vitamin E. Pharmaceutical vitamin E products should be used up soon after being bought or kept away any light sources.
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  Cite this Reference:
Pham Phuoc Nhan and Nguyen Kim Hoa, 2013. Effect of Light and Storage Time on Vitamin E in Pharmaceutical Products.  British Journal of Pharmacology and Toxicology, 4(5): 176-180.
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ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
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