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2013 (Vol. 4, Issue: 5)
Article Information:

Studies on the Analgesic and Anti-inflammatory Properties of Hydro-alcohol Extract of Caralluma dalzielii N.E.Br (Asclepiadaceae) in Rats and Mice

A.H. Umar, M. Mabrouk, N.M. Danjuma and A. Yaro
Corresponding Author:  A.H. Umar 

Key words:  Acetic acid-induced abdominal constriction, analgesic, anti-inflammatory, Caralluma dalzielii, , ,
Vol. 4 , (5): 169-175
Submitted Accepted Published
March, 14, 2012 May 10, 2012 October 25, 2013
Abstract:

The analgesic and anti-inflammatory potentials of the hydro-alcohol extract of Caralluma dalzielii N.E.Br, a Nigerian traditional medicinal plant was studied using thermal and chemical-induced pain models and carrageenan-induced acute inflammation. The acute toxicity and the phytochemical constituents of the extract were also determined. The results showed that the extract at a dose of 80 mg/kg significantly (p<0.05) prolonged the pain reaction times in the hot-plate pain model at 30 and 60 min and reduced acetic acid-induced writhing in mice and decrease pain score in formalin induced pain in rats at all doses tested. The hydro-alcohol extract of Caralluma dalzielii N.E.Br demonstrated significant (p<0.05) anti-inflammatory activity against acute inflammation induced by carrageenan. The estimated LD50 of the extract was found to be 288.53 mg/kg. Phytochemical analysis revealed the presence of tannins, saponins, anthraquinones, glycosides and flavonoids. These findings indicate that the hydro-alcohol extract of Caralluma dalzielii has analgesic and anti-inflammatory properties and could be beneficial in alleviating painful inflammatory conditions
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  Cite this Reference:
A.H. Umar, M. Mabrouk, N.M. Danjuma and A. Yaro, 2013. Studies on the Analgesic and Anti-inflammatory Properties of Hydro-alcohol Extract of Caralluma dalzielii N.E.Br (Asclepiadaceae) in Rats and Mice.  British Journal of Pharmacology and Toxicology, 4(5): 169-175.
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ISSN (Online):  2044-2467
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