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Article Information:
Studies on the Analgesic and Anti-inflammatory Properties of Hydro-alcohol Extract of Caralluma dalzielii N.E.Br (Asclepiadaceae) in Rats and Mice
A.H. Umar, M. Mabrouk, N.M. Danjuma and A. Yaro
Corresponding Author: A.H. Umar
Submitted: March, 14, 2012
Accepted: May 10, 2012
Published: October 25, 2013 |
Abstract:
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The analgesic and anti-inflammatory potentials of the hydro-alcohol extract of Caralluma dalzielii N.E.Br, a Nigerian traditional medicinal plant was studied using thermal and chemical-induced pain models and carrageenan-induced acute inflammation. The acute toxicity and the phytochemical constituents of the extract were also determined. The results showed that the extract at a dose of 80 mg/kg significantly (p<0.05) prolonged the pain reaction times in the hot-plate pain model at 30 and 60 min and reduced acetic acid-induced writhing in mice and decrease pain score in formalin induced pain in rats at all doses tested. The hydro-alcohol extract of Caralluma dalzielii N.E.Br demonstrated significant (p<0.05) anti-inflammatory activity against acute inflammation induced by carrageenan. The estimated LD50 of the extract was found to be 288.53 mg/kg. Phytochemical analysis revealed the presence of tannins, saponins, anthraquinones, glycosides and flavonoids. These findings indicate that the hydro-alcohol extract of Caralluma dalzielii has analgesic and anti-inflammatory properties and could be beneficial in alleviating painful inflammatory conditions
Key words: Acetic acid-induced abdominal constriction, analgesic, anti-inflammatory, Caralluma dalzielii, , ,
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A.H. Umar, M. Mabrouk, N.M. Danjuma and A. Yaro, . Studies on the Analgesic and Anti-inflammatory Properties of Hydro-alcohol Extract of Caralluma dalzielii N.E.Br (Asclepiadaceae) in Rats and Mice. British Journal of Pharmacology and Toxicology, (5): 169-175.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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