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Abstract
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Article Information:
Effect of Soybean Oil Supplemented Diet on Fatty Acid Level and Lipid Profile of Albino Rats
Friday O. Uhegbu, Amadike E. Ugbogu, Kingsley C. Nwoku and Victor C. Ude
Corresponding Author: Friday O. Uhegbu
Submitted: March 07, 2013
Accepted: April 22, 2013
Published: August 25, 2013 |
Abstract:
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This aim of this study is to evaluate the effect of soybean oil supplemented diet on the fatty acid level and lipid profile of male albino rats. Forty healthy male albino rats weighing between 96-110 g and aged 6 weeks were used. The rats were placed randomly into four groups of ten animals each. Group 1 served as control and had no soybean oil in their feed. Group 2-4 was placed on soybean oil supplemented diet 10, 20 and 30% respectively. The experiment lasted for 14 days. The results showed that the animals had significant (p&ang 0.05) increase in body weight compared with the control. Triacylglycerol, phospholipid and total cholesterol level were also significantly (p<&ang 0.05) decreased, 80.46±3.76 to 78.46±3.22; 15.36±0.34 to 10.12±0.75; and 116.65±6.38 to 110.95±6.36 mg/dL respectively. Very Low Density Lipoprotein (VLDL) and Low Density Lipoprotein (LDL) were also significantly decreased, 15.56±2.56 to 13.45±2.76; 68.88±2.54 to 56.59±2.14 mg/dL respectively. However High Density Lipoprotein (HDL) showed significant (p&ang 0.05) increase 60.37±1.36 to 65.75±1.89 mg/dL. Cholesterol, triacylglycerol and fatty acids are significant and independent risk factors of adverse cardiovascular events. The clinical and nutritional implication of these results is discussed.
Key words: Arthrosclerosis, cardiovascular disease, cholesterol, lipogenesis, osteoarthritis, ,
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Cite this Reference:
Friday O. Uhegbu, Amadike E. Ugbogu, Kingsley C. Nwoku and Victor C. Ude, . Effect of Soybean Oil Supplemented Diet on Fatty Acid Level and Lipid Profile of Albino Rats. British Journal of Pharmacology and Toxicology, (4): 158-162.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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