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Abstract
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Article Information:
Effects of Aqueous Extract of Cyphostemma glaucophilla Leaves on Some Specific and Non-specific Immune Responses in Albino Rats
Ojogbane Eleojo, Omale James and Nwodo Okwesili Fred Chiletugo
Corresponding Author: Ojogbane Eleojo
Submitted: November 19, 2012
Accepted: January 11, 2013
Published: August 25, 2013 |
Abstract:
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Cyphostemma glaucophilla is used in the management of kwashiorkor, because impaired immune responses is associated with malnourishment the modulatory activity of aqueous leaves extract of Cyphostemma glaucophilla on primary and secondary humuoral responses, in vivo leucocyte mobilization, Delayed Type Hypersensitive Reaction (DTHR), haemoglobin, packed cell volume and white blood cell count were evaluated. The extract at 250 and 500 mg/kg stimulated significant (p&ang 0.05) dose dependent increase in primary and secondary sheep red blood cell specific antibody titre comparable to Levamisol. Extract at doses of 100 and 250 mg/kg induced leucocyte mobilization while 500 mg/kg inhibited leucocyte mobilization. The extract at 250 and 500 mg/kg produced significant (p&ang0.05) inhibition of DTHR in rats by 20.24 and 67.77%, respectively. The extract also induced significant (p&ang0.05) increases in packed cell volume by 3.0% at the lowest dose of 0.5 mg/kg and 11.2% at the highest dose of 2.0 mg/kg. However, the extract was insensitive to haemoglobin and total white blood cell count. Result has established cellular and humoral immunomodulatory activities of Cyphostemma glaucophilla aqueous leaves extract.
Key words: Cyphostemma glaucophilla, humoral response, hypersensitivity, immunomodulatory, leucocyte mobilization, ,
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Abstract
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Cite this Reference:
Ojogbane Eleojo, Omale James and Nwodo Okwesili Fred Chiletugo, . Effects of Aqueous Extract of Cyphostemma glaucophilla Leaves on Some Specific and Non-specific Immune Responses in Albino Rats. British Journal of Pharmacology and Toxicology, (4): 142-146.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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