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2013 (Vol. 4, Issue: 3)
Article Information:

Lactogenic and Cytogenetic Effects of Ochratoxin A in Adult Male Rats and Pups

Duraid A. Abbas
Corresponding Author:  Duraid A. Abbas 

Key words:  Cytogenetic, lactogenic, OTA, rats and pups, , ,
Vol. 4 , (3): 101-105
Submitted Accepted Published
January 09, 2013 January 31, 2013 June 25, 2013
Abstract:

Lactogenic and cytogenic effects were studied for Ochratoxin (OTA) dosed daily orally throughout lactation period to four groups each consist of newly parturated female rats at doses (0, 60, 120, 180) Ķg/Kg. BW representing control, T1, T2, T3 group. Micronucleus test results indicated significant increase in number of fragmented and budding nuclei of T1, T2, T3 adult rat bone marrow in dose dependent manner in comparison with control group. The lactating results show no significant change in weekly pup groupís weight gain or length throughout lactating period. Alough there were no changes recorded in viability index of all pups groups, lactating index recorded considerable decline in T1, T2, T3 pups groups according with their adult OTA doses with maximum pups death at the third lactating week. Different histopathological lesions observed in pups liver, kidney and spleen that increase in severity proportionally with their OTA mother doses.
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  Cite this Reference:
Duraid A. Abbas, 2013. Lactogenic and Cytogenetic Effects of Ochratoxin A in Adult Male Rats and Pups.  British Journal of Pharmacology and Toxicology, 4(3): 101-105.
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ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
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