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Abstract
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Article Information:
Oxidative Stress, Antioxidant Status and DNA Damage in a Mercury Exposure Workers
Hasan F. Al-azzawie, Akram Umran and Nadhem H. Hyader
Corresponding Author: Hasan F. Al-Azzawie
Submitted: December 17, 2012
Accepted: February 01, 2013
Published: June 25, 2013 |
Abstract:
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The present study was designed to evaluate changes in peripheral markers of oxidative stress, oxidative DNA damage and some biochemical markers during chronic HgCl2 intoxication and to examine how the workers respond chronically to this pollutant. Fifty (50) fasting male workers, age range 28-61 years exposed to mercury in a chloroalkali factory at Al-Furat company in Babylon governorate, range duration period 5-18 years and 30 controls matched for age, diet and other demographic characteristics except exposure to chemicals were selected. Lipid peroxidation marker Malondialdehyde (MDA), antioxidant status markers enzymatic Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), non enzymatic antioxidant markers, Glutathione (GSH), vitamin C, vitamin E and oxidative DNA damage by comet assay were determined. Blood Mercury levels were significantly higher in the workers G2 and G3 groups compared with controls group G1 (p<0.01). MDA levels were also significantly increased and positively correlated with the concentration of Hg in group 3 (r = 0.76, p<0.01), probably to match the body chemical burden, while levels of non enzymatic antioxidant GSH, vitamin C, E and enzymatic antioxidant SOD and GPx were in contrast significantly lower in both workers than in controls (p<0.01). The present study indicates that workers occupationally exposed to mercury, in the particular conditions of exposure of this collective evaluated, show clear evidence of genotoxic activity in their lymphocytes especially in G3 than G2 against healthy control group G1 and this genotoxic activity (DNA damage by comet assay) is correlated positively with the long period of exposure to mercury pollution. DNA damage in mercury-exposed individuals suggests that mercury overload induces an imbalance in the redox cycle.
Key words: DNA damage, inorganic mercury, oxidative stress biomarkers, , , ,
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Abstract
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Cite this Reference:
Hasan F. Al-azzawie, Akram Umran and Nadhem H. Hyader, . Oxidative Stress, Antioxidant Status and DNA Damage in a Mercury Exposure Workers. British Journal of Pharmacology and Toxicology, (3): 80-88.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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