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    Abstract
2012 (Vol. 3, Issue: 5)
Article Information:

Some of the Regenerative Properties of the Aqueos Extract of Ocimum sanctum on the Cytoarchitecture of the Liver of Adult Female Wistar Rats Following Paracetamol Induced Liver Damage

S.B. Mesole, Y.G. Mohammed, C. Nyaribo, J. Olusakin and A.O. Okpanachi
Corresponding Author:  S.B. Mesole 

Key words:  Cytoarchitecture, hepatic necrosis, hepatoregenerative, liver damage, Ocimum sanctum, paracetamol,
Vol. 3 , (5): 230-232
Submitted Accepted Published
May 18, 2012 June 15, 2012 October 25, 2012
Abstract:

The aim of the present study is to investigate some of the regenerative properties of Ocimum sanctum on the cytoarchitecture of the liver of adult female wistar rats following paracetamol induced liver damage. There is a lack of good hepatoregenerative drugs in modern medicine to aleviate and treat drug-induced liver damage. Leaves of sacred holy basil, also called Green Tulsi (Ocimum sanctum), belonging to family Lamiaceae are used traditionally for their hepatoregenerative effect. We wanted to evaluate the hepatoregenerative activity of Ocimum sanctum on paracetamol induced liver damage among female adult waster rats. At the end of this research which lasted for 14 days, remarkable and appreciable improvement was noticed in the appearance of the cytoarchitecture of the liver and reduction in sinusoidal congestion, cloudy swelling and fatty changes and regenerative areas of the liver were observed on histopathological examination in groups of the liver of group II and III that was administered variable dosage of the extract as compared to the group I which displayed only hepatic necrosis. We concluded from the result of our research that aqueous extract of Ocimum sanctum shows hepatoregenerative activity.
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  Cite this Reference:
S.B. Mesole, Y.G. Mohammed, C. Nyaribo, J. Olusakin and A.O. Okpanachi, 2012. Some of the Regenerative Properties of the Aqueos Extract of Ocimum sanctum on the Cytoarchitecture of the Liver of Adult Female Wistar Rats Following Paracetamol Induced Liver Damage .  British Journal of Pharmacology and Toxicology, 3(5): 230-232.
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