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Abstract
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Article Information:
Prophylactic Role of Echinacea, Green Tea and Boswellia Extracts in Pyloric Ligation-Induced Gastric Ulcer in Rats
Souty M. Sharkawi, Gamal Ahmed El-Sherbiny, Afaf A. Ain-Shoka and Mostafa E. El-Sayed
Corresponding Author: Souty M. Sharkawi
Submitted: April 12, 2012
Accepted: May 06, 2012
Published: October 25, 2012 |
Abstract:
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Peptic ulcer is a common disorder of the stomach and duodenum. Herbs and medicinal plants are
considered to be a potential source to combat various diseases including gastric ulcer. The present study was
conducted to evaluate the gastro protective effects of Echinacea extract, Green tea extract and Boswellia extract on a
pyloric ligation-induced gastric ulcer. Six groups of rats were intraperitoneally pre-treated with saline as normal
group, saline as ulcer group, 20 mg/kg of ranitidine as positive group, Echinacea extract (25 mg/kg, I.P), Green tea
extract (25 mg/kg, I.P) and Boswellia extract (200 mg/kg, I.P) for 15 consecutive days before pyloric ligation.
Gastric acidity, ulcer index and histology were assessed. Gastric homogenates were determined for
Malondialdehyde (MDA) content, Glutathione (GSH) content in addition to blood Superoxide Dismutase (SOD)
activity. Pyloric ligation elevated gastric acidity, ulcer index and malondialdehyde content, while glutathione
content and superoxide dismutase activity were significantly decreased. Prior administration of extracts mitigated
the injurious effects of pyloric ligation. Echinacea, Green tea and Boswellia extracts separately ameliorated all the
altered biochemical parameters. These results were confirmed histologically. These data suggested that Green tea,
Echinacea or Boswellia extract could have a protective role in gastric ulcer probably via regulation of oxidant/antioxidant
balance.
Key words: Boswellia, echinacea, gastric ulcer, green tea, pyloric ligation, ,
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Abstract
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Cite this Reference:
Souty M. Sharkawi, Gamal Ahmed El-Sherbiny, Afaf A. Ain-Shoka and Mostafa E. El-Sayed, . Prophylactic Role of Echinacea, Green Tea and Boswellia Extracts in Pyloric Ligation-Induced Gastric Ulcer in Rats. British Journal of Pharmacology and Toxicology, (5): 197-204.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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