|
Abstract
|
Article Information:
Analysis of Spermatogenesis and CREM Gene Expression in Testis of Rat Treated with Matricaria recutita
Fereshteh Javadian and Jasem Estakhr
Corresponding Author: Fereshteh Javadian
Submitted: June 28, 2012
Accepted: August 08, 2012
Published: August 25, 2012 |
Abstract:
|
Camp-Responsive Element Modulator (CREM) is a key factor in the regulation of the expression of
number of post-meiotic genes during spermatogenesis. Matricaria recutita shows different pharmacological
activities like anti-inflammatory, anti-cancer, treatment of stress and depression, anti-allergic and etc. The objectives
of this study are to investigate effects of Matricaria recutita on spermatogenesis and CREM expression at MRNA
level. Animals were divided into 3 groups with 7 rats in each. The extract administered orally in the doses 100 and
150 mg/kg/day to rats for 56 consecutive days. Sperm analysis and RT-PCR were carried out to investigate rat
reproductive function. Results indicated significant decrease in the epididymal sperm counts and sperm motility of
experimental groups compared to control group. Reverse Transcription Polymerase Chain Reaction (RT-PCR)
showed a decrease in the expression of CREM in the testes of experimental groups. From the data it can be
concluded that Matricaria recutita has anti-spermatogenic properties.
Key words: CREM gene expression , Matricaria recutita, spermatogenesis, , , ,
|
|
Abstract
|
PDF
|
HTML |
|
Cite this Reference:
Fereshteh Javadian and Jasem Estakhr, . Analysis of Spermatogenesis and CREM Gene Expression in Testis of Rat Treated with Matricaria recutita. British Journal of Pharmacology and Toxicology, (4): 181-184.
|
|
|
|
 |
ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
 |
| Information |
|
|
|
|
| Sales & Services |
|
|
|
|
