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Abstract
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Article Information:
N-nitrosodimethylamine (NDMA), Liver Function Enzymes, Renal Function Parameters and Oxidative Stress Parameters: A Review
Usunobun Usunomena, Adegbegi J. Ademuyiwa, O. Okugbo Tinuade, F. Evuen Uduenevwo, Osibemhe Martin and N.P. Okolie
Corresponding Author: Usunobun Usunomena
Submitted: June 15, 2012
Accepted: July 18, 2012
Published: August 25, 2012 |
Abstract:
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The aim of this study is to review a procarcinogen, the N-Nitrosodimethylamine (NDMA), liver and
kidney functional enzymes (in assessing action of toxicants such as NDMA) as well as oxidative stress parameters
(in assessing the extent of free radical damage and scavenging). Catalase and hydro peroxidase enzymes convert
hydrogen peroxide and hydro peroxides to non-radical forms and functions as natural antioxidant in human body.
Enzymes like Superoxide Dismutase (SOD) and Catalase (CAT) and compounds such as tocopherol and ascorbic
acid can protect organisms against free radical damage. Lipid peroxidation is a mechanism generally recognized as
being the most important in the pathogenesis of liver injury by a number of toxic compounds including NDMA.
Key words: Carcinogenesis, CYP2E1, liver, N-nitrosodimethylamine, renal, ROS,
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Cite this Reference:
Usunobun Usunomena, Adegbegi J. Ademuyiwa, O. Okugbo Tinuade, F. Evuen Uduenevwo, Osibemhe Martin and N.P. Okolie, . N-nitrosodimethylamine (NDMA), Liver Function Enzymes, Renal Function Parameters and Oxidative Stress Parameters: A Review. British Journal of Pharmacology and Toxicology, (4): 165-176.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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