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    Abstract
2012 (Vol. 3, Issue: 4)
Article Information:

N-nitrosodimethylamine (NDMA), Liver Function Enzymes, Renal Function Parameters and Oxidative Stress Parameters: A Review

Usunobun Usunomena, Adegbegi J. Ademuyiwa, O. Okugbo Tinuade, F. Evuen Uduenevwo, Osibemhe Martin and N.P. Okolie
Corresponding Author:  Usunobun Usunomena 

Key words:  Carcinogenesis, CYP2E1, liver, N-nitrosodimethylamine, renal, ROS,
Vol. 3 , (4): 165-176
Submitted Accepted Published
June 15, 2012 July 18, 2012 August 25, 2012
Abstract:

The aim of this study is to review a procarcinogen, the N-Nitrosodimethylamine (NDMA), liver and kidney functional enzymes (in assessing action of toxicants such as NDMA) as well as oxidative stress parameters (in assessing the extent of free radical damage and scavenging). Catalase and hydro peroxidase enzymes convert hydrogen peroxide and hydro peroxides to non-radical forms and functions as natural antioxidant in human body. Enzymes like Superoxide Dismutase (SOD) and Catalase (CAT) and compounds such as tocopherol and ascorbic acid can protect organisms against free radical damage. Lipid peroxidation is a mechanism generally recognized as being the most important in the pathogenesis of liver injury by a number of toxic compounds including NDMA.
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  Cite this Reference:
Usunobun Usunomena, Adegbegi J. Ademuyiwa, O. Okugbo Tinuade, F. Evuen Uduenevwo, Osibemhe Martin and N.P. Okolie, 2012. N-nitrosodimethylamine (NDMA), Liver Function Enzymes, Renal Function Parameters and Oxidative Stress Parameters: A Review.  British Journal of Pharmacology and Toxicology, 3(4): 165-176.
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