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    Abstract
2012 (Vol. 3, Issue: 3)
Article Information:

Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken

A. El-Mahmoudy, M.E. Mahmoud, K. Fararh, M. Draid, A. El-Magdoub and S. Awidat
Corresponding Author:  A. El-Mahmoudy 

Key words:  B-cells, broiler chickens, bursa of fabricius, Major Histocompatibility Complex Class II (MHC-II), sulphadimidine, ,
Vol. 3 , (3): 135-139
Submitted Accepted Published
April 20, 2012 May 10, 2012 June 30, 2012
Abstract:

The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken were used, the first two groups received 100 mg/kg and 200 mg/kg sulfadimidine, respectively, in drinking water; while the third group was left as control. Bursal samples were taken after 7 and 14 days of treatment and checked for MHC-II gene expression by RT-PCR technique. The obtained results demonstrate that oral administration of sulphadimidine inhibited the expression of MHC-II mRNA in bursal of Fabricius of broiler chicken in a dose and age dependent manner. This finding is of clinical importance as many farmers routinely add sulpha drugs to drinking water as a prophylactic measure against some infections; yet the data presented in this study doesn't recommend this managing behavior.
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  Cite this Reference:
A. El-Mahmoudy, M.E. Mahmoud, K. Fararh, M. Draid, A. El-Magdoub and S. Awidat, 2012. Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken.  British Journal of Pharmacology and Toxicology, 3(3): 135-139.
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ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
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