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2012 (Vol. 3, Issue: 3)
Article Information:

Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken

A. El-Mahmoudy, M.E. Mahmoud, K. Fararh, M. Draid, A. El-Magdoub and S. Awidat
Corresponding Author:  A. El-Mahmoudy 

Key words:  B-cells, broiler chickens, bursa of fabricius, Major Histocompatibility Complex Class II (MHC-II), sulphadimidine, ,
Vol. 3 , (3): 135-139
Submitted Accepted Published
April 20, 2012 May 10, 2012 June 30, 2012

The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken were used, the first two groups received 100 mg/kg and 200 mg/kg sulfadimidine, respectively, in drinking water; while the third group was left as control. Bursal samples were taken after 7 and 14 days of treatment and checked for MHC-II gene expression by RT-PCR technique. The obtained results demonstrate that oral administration of sulphadimidine inhibited the expression of MHC-II mRNA in bursal of Fabricius of broiler chicken in a dose and age dependent manner. This finding is of clinical importance as many farmers routinely add sulpha drugs to drinking water as a prophylactic measure against some infections; yet the data presented in this study doesn't recommend this managing behavior.
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  Cite this Reference:
A. El-Mahmoudy, M.E. Mahmoud, K. Fararh, M. Draid, A. El-Magdoub and S. Awidat, 2012. Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken.  British Journal of Pharmacology and Toxicology, 3(3): 135-139.
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ISSN (Online):  2044-2467
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