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Abstract
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Article Information:
Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken
A. El-Mahmoudy, M.E. Mahmoud, K. Fararh, M. Draid, A. El-Magdoub and S. Awidat
Corresponding Author: A. El-Mahmoudy
Submitted: April 20, 2012
Accepted: May 10, 2012
Published: June 30, 2012 |
Abstract:
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The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by
investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are
one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken
were used, the first two groups received 100 mg/kg and 200 mg/kg sulfadimidine, respectively, in
drinking water; while the third group was left as control. Bursal samples were taken after 7 and 14
days of treatment and checked for MHC-II gene expression by RT-PCR technique. The obtained
results demonstrate that oral administration of sulphadimidine inhibited the expression of MHC-II
mRNA in bursal of Fabricius of broiler chicken in a dose and age dependent manner. This finding is
of clinical importance as many farmers routinely add sulpha drugs to drinking water as a prophylactic
measure against some infections; yet the data presented in this study doesn't recommend this
managing behavior.
Key words: B-cells, broiler chickens, bursa of fabricius, Major Histocompatibility Complex Class II (MHC-II), sulphadimidine, ,
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Cite this Reference:
A. El-Mahmoudy, M.E. Mahmoud, K. Fararh, M. Draid, A. El-Magdoub and S. Awidat, . Sulphadimidine Suppresses Major Histocompatibility Complex (MHC) Expression in Broiler Chicken. British Journal of Pharmacology and Toxicology, (3): 135-139.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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