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Abstract
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Article Information:
Erythrocyte Glutathione Peroxidase, Serum Selenium, Lipids and Lipoproteins in Human Immunodeficiency Virus Positive Blood Donors
M.O. Ebesunun, O.O. Faniran and K.J. Adetunji
Corresponding Author: M.O. Ebesunun
Submitted: March 15, 2012
Accepted: March 30, 2012
Published: June 30, 2012 |
Abstract:
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The study was designed to assess the relationship between red cell glutathione peroxidase and serum
selenium as well as lipids and lipoprotein in HIV positive blood donors. Thirty five subjects consisting of
twenty HIV positive blood donors with a mean age of 34±2.18 years and fifteen HIV negative blood donors
with a mean age of 43±2.18 years controls were selected for this study. Erythrocyte glutathione peroxidase,
lipids and lipoprotein were estimated using colorimetric methods. Serum selenium was determined by atomic
absorption spectrophotometer. The anthropometric indices were determined using standard techniques. The
mean body mass index was significantly reduced in HIV patients when compared with the controls. Significant
decrease mean value was obtained in the erthrocyteglutathi one peroxidase (p<0.01) while significant increases
were observed in serum triglycerides (p<0.01) and total cholesterol (p<0.05) compared with the control values.
Erythrocyte glutathione peroxidase was significantly correlated with total cholesterol (r = 0.603, p<0.05) and
low density lipoprotein cholesterol (r = 0.605, p<0.05). Decreased cellular antioxidant such as erythrocyte
glutathione peroxidase, increased TC and TG were observed in HIV positive blood donors in the present study.
Key words: Gluthathione, HIV lipids, peroxidase, selenuim, , ,
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Abstract
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Cite this Reference:
M.O. Ebesunun, O.O. Faniran and K.J. Adetunji, . Erythrocyte Glutathione Peroxidase, Serum Selenium, Lipids and Lipoproteins in Human Immunodeficiency Virus Positive Blood Donors. British Journal of Pharmacology and Toxicology, (3): 119-122.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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