Home           Contact us           FAQs           
 
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
    Abstract
2012 (Vol. 3, Issue: 3)
Article Information:

Antioxidant Effect of Carica papaya on Ethanol Induced Gastric Lesion in Adult Male Wistar Rats

A.A. Okesina, S.B. Mesole, J. Olusakin, Y.G. Mohammed, A.A. Mohammed, M.O. Buhari, J.O. Ashaolu, I. Ezekiel, A.D.T. Goji and E.A. Caxton-Martins
Corresponding Author:  A.A. Okesina 

Key words:  Carica papaya (CPL), enzyme, glucose-6-phosphate dehydrogenase (G6PDH), glutathione peroxidase (GPx), stomach, thiobarbituric acid test (TBARS),
Vol. 3 , (3): 98-101
Submitted Accepted Published
June 02, 2011 December 09, 2011 June 30, 2012
Abstract:

This study was performed to elucidate the role of some important constituents of antioxidant defence such as Glutathione Peroxidase (GPx), Thiobarbituric Acid Reaction (TBAR), the activity of the enzyme Glucose-6-Phosphate Dehydrogenase (G-6-PDH) of Carica papaya on ethanol induced gastric lesion in adult male wistar rats. Twenty-four male adult Wistar rats weighing 180- 220 g were used in this study. Animals were divided into three groups (n = 8 per group). The control group A received phosphate buffered saline orally, with the aid of a cannula. 1 mL of 50% ethanol was administered orally, by a cannula, to produce the gastric lesion in group B (n = 8). And in the group C, 500 mg/kg body weight of paw paw leaf extract was administered orally, with a cannula, twelve hours after ethanol administration to the rats. This experiment lasted for twenty one consecutive days. The result showed that TBARS in gastric mucosa as an index for oxidative stress level was significantly increased after ethanol administration. CPL did not reduce significantly the levels of TBARS in the gastric mucosa. G-6-PDH activity was significantly increased in gastric mucosa after ethanol administration, but in rats treated with CPL, a reverse of G-6-PDH activity was observed. Ethanol induced a remarkable and significant decrease of GPx activity in gastric mucosa, whereas CPL induced a significant reversion of ethanolís effect on the enzyme. The results therefore demonstrate that CPL treatment exerts antioxidant effects on ethanol-induced gastric lesions in wistar rats.
Abstract PDF HTML
  Cite this Reference:
A.A. Okesina, S.B. Mesole, J. Olusakin, Y.G. Mohammed, A.A. Mohammed, M.O. Buhari, J.O. Ashaolu, I. Ezekiel, A.D.T. Goji and E.A. Caxton-Martins, 2012. Antioxidant Effect of Carica papaya on Ethanol Induced Gastric Lesion in Adult Male Wistar Rats.  British Journal of Pharmacology and Toxicology, 3(3): 98-101.
    Advertise with us
 
ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved