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Abstract
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Article Information:
Quinpirole Effects on the Dopaminergic System
Bolaños-Jiménez Rodrigo, Arizmendi-Vargas Jorge, Martínez-Zavala Néstor, Carrillo-Ruiz José Damián, Calderón Álvarez-Tostado José Luis, Jiménez-Ponce Fiacro and Rivera-Silva Gerardo
Corresponding Author: Bolaños-Jiménez Rodrigo
Submitted: 2011 August, 30
Accepted: 2011 October, 07
Published: 2011 December, 20 |
Abstract:
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Quinpirole (QNP) is a D2-like dopamine (DA) receptor agonist with some selectivity for D3
receptors, and it is the active enantiomer of quinpirole dihydrochloride. The objective of the present article is
to review the available evidence published about dopamine in the Central and Peripheral Nervous System
(CNS, PNS) and QNP with an emphasis on their receptors effects, the physiological and molecular changes in
CNS cells. Dopaminergic neurons are the most important cells regarding reward-related behavior; they are also
involved in many neuroanatomical pathways and different functions both in central (locomotion control,
cognition, motivation, learning, sleep-wake cycles, etc.), peripheral and autonomous nervous system; however,
the correlation between dopamine release and cell firing is unclear. Also, other cellular mechanisms regarding
DA have not been completely studied. This is why animal models with rats and QNP are still used for studying
the role of DA and its physiological and pathological implications in the nervous system. Animal models of
Obsessive-Compulsive Disorder (OCD) have been successfully reproduced in rats with the manipulation of
dopaminergic system using QNP, as an association between the dopaminergic system and the production of
compulsive behaviors has been evidenced. Moreover, QNP and DA modulate neurons through the activation
of cytoplasmic cascades, intracellular receptor stimulation and even through gene transcription regulation.
Key words: Behavior, central nervous system, cytoplasmic cascades, dopamine, d2 receptor agonist, obsessive compulsive disorder, peripheral nervous system, quinpirole
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Cite this Reference:
Bolaños-Jiménez Rodrigo, Arizmendi-Vargas Jorge, Martínez-Zavala Néstor, Carrillo-Ruiz José Damián, Calderón Álvarez-Tostado José Luis, Jiménez-Ponce Fiacro and Rivera-Silva Gerardo, . Quinpirole Effects on the Dopaminergic System. British Journal of Pharmacology and Toxicology, (6): 310-317.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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